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Cat. No.: HY-W070739

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GABAA receptor modulator-12

GABAA receptor modulator-12 (Compound 5) is a GABA_A receptor modulator. GABAA receptor modulator-12 inhibits anesthetic-induced desensitization of GABA_A α3β3γ2 receptors with an IC₅₀ of 0.2 μM. GABAA receptor modulator-12 can be used in the research of central nervous system disorders.

For research use only. We do not sell to patients.

CAS No.: 6252-98-8
Formula: C₁₁H₁₀N₂O₂
Molecular Weight:202.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

GABAA receptor modulator-12 Chemical Structure

CAS No.: 6252-98-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

IC₅₀: 0.2 μM (anesthetic-induced desensitization of GABA_A α3β3γ2 receptors)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-5-2	CC₅₀	>10 μM Compound: 4	Cytotoxicity against human HuH5.2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HuH5.2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31303998]
L6	CC₅₀	>500 μM Compound: 4	Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 6 days by resazurin dye based fluorescence assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 6 days by resazurin dye based fluorescence assay	[PMID: 31303998]

Chemical Information

CAS No. 6252-98-8
Molecular Weight 202.21
Formula C₁₁H₁₀N₂O₂
SMILES

O=C(C1(C(C=CC=C2)=C2CC1)N3)NC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Koinas DA, et al. Spiro Hydantoins Can Reverse the Action of Positive Allosteric Modulators on GABAARs. ACS Med Chem Lett. 2025 Sep 30;16(10):2078-2083. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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