Halofenozide
Based on 1 Customer Validation
Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone.
For research use only. We do not sell to patients.
- Purity: 99.42%
- CAS No.: 112226-61-6
- Formula: C18H19ClN2O2
- Molecular Weight:330.81
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Halofenozide (RH-0345) reduces both growth and development of oocytes in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Cultured ovaries were dissected from female adult beetles of mealworm, Tenebrio molitor (T. molitor)
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Concentration:1 μM and 10 μM
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Incubation Time:4 days
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Result:Did not cause a significant effect on ecdysteroid amounts in the culture medium using ovaries from 0- and 2-day-old females at 10 μM.
Caused a small significant increase of the amounts of ovarian ecdysteroids in the culture medium at 1 μM in the culture medium and with 2-day-old ovaries.
Halofenozide at the two doses tested (5 and 10 μg) causes smaller eggs with a decrease in length, width and volume[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Newly emerged (0-day-old) adult females of T. molitor [1]
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Dosage:5 and 10 μg
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Administration:Topically applied
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Result:Caused smaller eggs with a decrease in length, width and volume at the two doses tested (5 and 10 μg) .
Chemical Information
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CAS No. 112226-61-6
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Appearance Solid
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Molecular Weight 330.81
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Formula C18H19ClN2O2
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Color White to off-white
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SMILES
O=C(NN(C(C1=CC=CC=C1)=O)C(C)(C)C)C2=CC=C(Cl)C=C2
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Synonyms
RH-0345
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (377.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (272 KB)
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SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Portuguese - PT (537 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0229 mL | 15.1144 mL | 30.2288 mL | 75.5721 mL |
| 5 mM | 0.6046 mL | 3.0229 mL | 6.0458 mL | 15.1144 mL | |
| 10 mM | 0.3023 mL | 1.5114 mL | 3.0229 mL | 7.5572 mL | |
| 15 mM | 0.2015 mL | 1.0076 mL | 2.0153 mL | 5.0381 mL | |
| 20 mM | 0.1511 mL | 0.7557 mL | 1.5114 mL | 3.7786 mL | |
| 25 mM | 0.1209 mL | 0.6046 mL | 1.2092 mL | 3.0229 mL | |
| 30 mM | 0.1008 mL | 0.5038 mL | 1.0076 mL | 2.5191 mL | |
| 40 mM | 0.0756 mL | 0.3779 mL | 0.7557 mL | 1.8893 mL | |
| 50 mM | 0.0605 mL | 0.3023 mL | 0.6046 mL | 1.5114 mL | |
| 60 mM | 0.0504 mL | 0.2519 mL | 0.5038 mL | 1.2595 mL | |
| 80 mM | 0.0378 mL | 0.1889 mL | 0.3779 mL | 0.9447 mL | |
| 100 mM | 0.0302 mL | 0.1511 mL | 0.3023 mL | 0.7557 mL |
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