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Referencia número: HY-112282

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BI-1408

Name: BI-1408
Brand: MedChemExpress
SKU: HY-112282
Price: 571.00 USD
Availability: InStock
Rating: 5 (1 reviews)

BI-1408 is a potent γ secretase modulator with an IC₅₀ of 0.04 μM for Aβ₄₂.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2231075-94-6
Fòrmula: C₂₂H₂₃FN₆
Peso molecular:390.46

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BI-1408 Chemical Structure

No. CAS: 2231075-94-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

BI-1408 is a potent γ secretase modulator with an IC₅₀ of 0.04 μM for Aβ₄₂^[1].

IC₅₀ & Target

IC50: 40 nM (Aβ₄₂)^[1]

Chemical Information

No. CAS 2231075-94-6
Peso molecular 390.46
Fòrmula C₂₂H₂₃FN₆
SMILES

CC1=CC(F)=CC=C1C2=CC=CN3C2=NC(N[C@@H]4CCC(N(CC)N=C5)=C5C4)=N3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Gerlach K, et al. Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators. Bioorg Med Chem. 2018 Jul 23;26(12):3227-3241. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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