Antimicrobial agent-5
Antimicrobial agent-5 is an potent antimicrobial agent, and displays excellent cell selectivity against Gram-negative bacteria and Gram-positive bacteria. Antimicrobial agent-5 blocks the interaction between LPS and CD14/TLR4 receptor, and shows anti-inflammatory activity against LPS-induced inflammation.
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- No. CAS: 2978694-04-9
- Fòrmula: C32H48N16
- Peso molecular:656.83
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Antimicrobial agent-5 (compound 9) (0.5-32 μg/mL, 16 h; 1-128 μg/mL; 24 h) shows potent biofilm inhibitory (IC50=2 μg/mL) and eradicating activities (IC50=16 μg/mL) against multidrug-resistant Pseudomonas aeruginosa (MDRPA)[1].
Antimicrobial agent-5 (5 μgmL, 20 μg/mL; 18 h) inhibits both the release and expression of nitric oxide (NO) and tumor necrosis factor-α (TNF-α) from LPS-stimulated (1 μg/mL) RAW 264.7 cells[1].
Antimicrobial agent-5 exhibits proteolytic resistance and salt/serum stability[1].
Antimicrobial agent-5 (0.5-256 μg/mL; 2 h) exhibits negligible side effects against sheep red blood cells (sRBCs) with hemolytic activity (the minimum hemolytic concentration, MHC) of >256 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells
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Concentration:5 μg/mL, 20 μg/mL
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Incubation Time:18 hours
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Result:Decreased TNF-α release at 20 μg/mL, with inhibition rate of 72.44%.
Results reduction in the LPS-stimulated production of NO, with inhibition rate of 31.51%.
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Cell Line:E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917], S. aureus [KCTC1621]
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Concentration:1-128 μg/mL
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Incubation Time:24 hours
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Result:Inhibited Gram-negative bacteria and Gram-positive bacteria with IC50 of 6.1 μM (E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917], S. aureus [KCTC1621]), respectively.
Chemical Information
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No. CAS 2978694-04-9
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Peso molecular 656.83
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Fòrmula C32H48N16
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SMILES
NCCNC1=NC(NCCN)=NC(N(C(CN2C3=NC(NCCN)=NC(NCCN)=N3)CC4=CC=CC=C4)CC2CC5=CC=CC=C5)=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimicrobial agent-5 Related Classifications
HY-151399 Related Classifications
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