Arcapillin
Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin induces dose-dependent relaxation of ileum and pulmonary artery smooth muscle, causes slight urinary bladder smooth muscle contraction at highest tested concentrations. Arcapillin binds to the active site of SARS-CoV-2 Mpro via interactions with Gln139, His163, and His164, exhibits antiviral activity against SARS-CoV-2 and MERS-CoV. Arcapillin can be used for the research of gastrointestinal disorders, COVID-19, and Middle East respiratory syndrome (MERS).
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- No. CAS: 83162-82-7
- Fòrmula: C18H16O8
- Peso molecular:360.31
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
PTP1B[1]
Arcapillin binds to the SARS-CoV-2 main protease (PDB: 7L0D) with a docking score of -6.16 kcal mol−1, indicating favorable interactions with the enzyme's active site[2].
Arcapillin (72 h) exhibits antiviral activity against SARS-CoV-2 in Vero E6 cells with an IC50 of 190.8 μg mL−1, and has a low cytotoxic profile in the same cell line with a CC50 of 1228 μg mL−1, yielding a selectivity index of 6.40[2].
Arcapillin (72 h) exhibits potent antiviral activity against MERS-CoV in Vero E6 cells with an IC50 of 16.58 μg mL−1, and has a CC50 of 54.17 μg mL−1 in the same cell line, yielding a selectivity index of 3.26[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 83162-82-7
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Peso molecular 360.31
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Fòrmula C18H16O8
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SMILES
O=C1C=C(C2=CC(OC)=C(O)C=C2O)OC3=CC(OC)=C(OC)C(O)=C13
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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