AZ'320
AZ'320 is an ATP-competitive necroptosis (EC50 of 4.9 μM) inhibitor and a RIPK1 (pKD of 5.45) inhibitor. AZ'320 inhibits necroptosis by inhibiting RIPK1 phosphorylation. AZ’320 prevents mortality of the mice and rescues temperature and body weight in SIRS mice models. AZ'320 can be used for researches of cancer and inflammation.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C20H20N2O4S2
- Peso molecular:416.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
AZ’320 (0.1-10 μM, 4 h) dose-dependently inhibits the levels of RIPK1 Ser166 phosphorylation in I2.1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:I2.1 FADD−/− human Jurkat cells
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Concentration:01, 1, 5 and 10 μM
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Incubation Time:4 h
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Result:Dose-dependently inhibited the levels of RIPK1 Ser166 phosphorylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Systemic inflammatory response syndrome (SIRS) mice models (C57BL/6, male, 6-8 weeks)[1]
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Dosage:5 mg/kg
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Administration:Intravenously injection, 15 min before 96 h of 0.5 mg/kg TNF stimulation
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Result:Prevented mortality of the mice and rescued temperature and body weight to a similar degree as Nec-1 (HY-15760).
Chemical Information
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Peso molecular 416.51
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Fòrmula C20H20N2O4S2
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SMILES
O=S(C1=CC=C(C2=CC=C3C=CC=NC3=C2)C=C1)(N4CC(CS(=O)(C)=O)C4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AZ'320 Related Classifications
HY-174820 Related Classifications
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