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Referencia número: HY-133439

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BCN-PEG4-NHS ester

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BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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Pureza: 95.0%
No. CAS: 1702356-19-1
Fòrmula: C₂₆H₃₈N₂O₁₀
Peso molecular:538.59

Almacenamiento:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

BCN-PEG4-NHS ester Chemical Structure

No. CAS: 1702356-19-1

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
Chemical Information
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Referencias
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Actividad biológica

Descripciòn

BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

PEGs	Alkyl/ether

Ver todos los productos específicos de isoformas PROTAC Linkers :

Ver todos los productos específicos de isoformas ADC Linkers :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1702356-19-1
Appearance Liquid
Peso molecular 538.59
Fòrmula C₂₆H₃₈N₂O₁₀
Color Colorless to light yellow
SMILES

[H][C@@]12[C@@](CCC#CCC2)([H])[C@@H]1COC(NCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. "An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. " [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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BCN-PEG4-NHS ester

Ver todos los productos específicos de isoformas PROTAC Linkers

Ver todos los productos específicos de isoformas ADC Linkers

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

BCN-PEG4-NHS ester Related Classifications

HY-133439 Related Classifications