β-Bisabolol
β-Bisabolol is a potent anti-inflammatory agent that can be found in cotton gin trash. β-Bisabolol inhibits the production of nitric oxide (NO), pGE2, TNF-α, IL-6, and IL-8 in LPS (HY-D1056)-stimulated macrophages and fibroblast cells. β-Bisabolol can be used for the research on inflammatory conditions.
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- No. CAS: 15352-77-9
- Fòrmula: C15H26O
- Peso molecular:222.37
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
IL-6 |
IL-8 |
In Vitro
β-Bisabolol (1.6-100.0 μg/mL; 24 h) is non-toxic to RAW 264.7 macrophages, 3t3 fibroblasts, and HS27 fibroblasts up to 50 μg/mL, with slight toxicity observed at 100.0 μg/mL[1].
β-Bisabolol (1.6-50.0 μg/mL; 1 h pretreat) dose-dependently inhibits the production of NO, PGE2, and TNF-α in LPS-stimulated RAW 264.7 macrophages, as well as IL-6 (with EC50 values of 4.3 μg/mL in 3T3, 8.8 μg/mL in HS27, respectively) and IL-8 in LPS-stimulated fibroblast cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:RAW 264.7, 3t3, HS27 cells
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Concentration:1.6, 3.1, 6.3, 12.5, 25.0, 50.0, 100.0 μg/mL
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Incubation Time:24 h
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Result:Found no effect on cell viability at concentrations up to 50.0 μg/mL in RAW 264.7, 3t3 and HS27 cells.
Showed slight toxicity at 100.0 μg/mL in RAW 264.7, 3t3 and HS27 cells.
Chemical Information
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No. CAS 15352-77-9
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Peso molecular 222.37
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Fòrmula C15H26O
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SMILES
[C@@H](CCC=C(C)C)(C)[C@]1(O)CCC(C)=CC1
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
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Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-Bisabolol Related Classifications
HY-W750980 Related Classifications
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