BMS-223131
BMS-223131 (Compound 1) is a potent maxi-K potassium channel opener. BMS-223131 has a strong inhibitory effect on the CYP2C9 enzyme (IC50 = 1.7 μM) and also shows varying degrees of inhibition on other common CYP enzymes such as CYP1A2, CYP2C19, CYP2D6, and CYP3A4. BMS-223131 can enhance the outward current mediated by maxi-K, by promoting K+ efflux to hyperpolarize the cell membrane and reducing Ca2+ influx. BMS-223131 can be used for the research of neurological disease, such as stroke.
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- No. CAS: 275375-69-4
- Fòrmula: C18H13ClF3NO3
- Peso molecular:383.75
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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CYP2C9 1.7 μM (IC50) |
CYP1A2 |
CYP2C19 |
CYP2D6 |
CYP3A4 |
Chemical Information
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No. CAS 275375-69-4
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Peso molecular 383.75
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Fòrmula C18H13ClF3NO3
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SMILES
O=C1NC2=C(C=C(C(F)(F)F)C=C2)C(C3=CC(Cl)=CC=C3O)=C1CCO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-223131 Related Classifications
HY-19397 Related Classifications
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