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Referencia número: HY-182435

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CLE-030

CLE-030 is a KCNQ2 agonist with non-gating-dependent current-modulating activity. CLE-030 modulates neuronal network activity. CLE-030 can be used in studies related to pain, epilepsy and benign familial neonatal convulsions.

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No. CAS: 2803111-66-0
Fòrmula: C₂₀H₂₀Br₂N₄OS₂
Peso molecular:556.34

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

CLE-030 Chemical Structure

No. CAS: 2803111-66-0

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Actividad biológica
- Descripciòn
- In Vitro
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Actividad biológica

Descripciòn

In Vitro

CLE-030 (Compound 34) (10 μM; for at least 3 min) increases channel currents in CHO-K1 cells transfected with human KCNQ2^[1].
CLE-030 (0.1-10 μM) potently activates wild-type human KCNQ2 channels expressed in CHO cells, with an EC₅₀ of 3.9 μM. It enhances channel currents without altering voltage sensitivity or gating kinetics^[2].
CLE-030 (0.1-10 μM) shows significantly reduced activation potency toward W236A, L299A, and V302A mutant KCNQ2 channels expressed in CHO cells^[2].
CLE-030 (0.1-10 μM) selectively activates human KCNQ2, KCNQ4 and KCNQ5 channels expressed in CHO cells, and exhibits no significant activity against KCNQ1, KCNQ3^A315T, BK_Ca, Kv1.2, Kir4.1 or TREK-1 channels^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2803111-66-0
Peso molecular 556.34
Fòrmula C₂₀H₂₀Br₂N₄OS₂
SMILES

O=C(CSC1=NN=C(CSCC2=CC=C(C)C=C2)N1C)NC3=CC=C(C=C3Br)Br
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Yang Huaiyu, et al. Triazole derivative and preparation method and application thereof. CN116763781A. 2023-09-19.

[2]. Liu S, et al. General Pharmacological Activation Mechanism of K⁺ Channels Bypassing Channel Gates. J Med Chem. 2022;65(15):10285-10299. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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