Complement C1s-IN-1
Based on 1 Customer Validation
Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 97.77%
- No. CAS: 3033831-40-9
- Fòrmula: C22H20F2N6O
- Peso molecular:422.43
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
IC50: 36 nM (C1s)[1]
Pharmacokinetic Parameters of Complement C1s-IN-1 in Male C57BL/6J mice[1].
| Dosage (mg/kg) | Cmax (ng/mL) | Tmax (h) | AUC(0-24h) (h* ng/mL) | MRT (h) |
| 10 | 1032.5±173.0 | 1.67±0.58 | 6017.8±390.4 | 4.31±0.23 |
| 30 | 2583.3±267.1 | 2.67±1.15 | 21928.6±1428.2 | 5.02±0.18 |
| 100 | 8895.9±1516.8 | 4.00±0.00 | 13934.1±36760.1 | 7.66±0.99 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6J mice[1]
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Dosage:10, 30, 100 mg/kg
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Administration:P.o.
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Result:Significantly inhibited MAC formation induced by human serum in a dose-dependent manner.
Chemical Information
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No. CAS 3033831-40-9
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Appearance Solid
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Peso molecular 422.43
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Fòrmula C22H20F2N6O
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Color Off-white to light yellow
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SMILES
NC1=C(C(F)=CC(N2C[C@H](C3=NOC(C)=C3)N(C4=CC(F)=CC=C4)CC2)=C5)C5=CN=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Complement C1s-IN-1 Related Classifications
HY-149278 Related Classifications
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