DHODH-IN-23
Based on 1 Customer Validation
DHODH-IN-23 (Compound A) is an orally active DHODH inhibitor that can be used for the research of cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.75%
- No. CAS: 1346705-53-0
- Fòrmula: C24H21ClFNO4
- Peso molecular:441.88
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-128068
DHODH-IN-17DHODH Inhibitor -
HY-137463
AG-636DHODH Inhibitor -
HY-129239
FarudodstatDHODH Inhibitor -
HY-100688
ML390DHODH Inhibitor -
HY-139189
JNJ-74856665DHODH Inhibitor -
HY-128787
hDHODH-IN-4DHODH Inhibitor -
HY-135570
hDHODH-IN-3HsDHODH Inhibitor -
HY-132174
CHIKV-IN-2CHIKV Inhibitor -
HY-135675
DHODH-IN-11Rat DHODH Inhibitor -
HY-112645
BAY-2402234DHODH Inhibitor -
HY-101813
LaflunimusImmunomodulator/DHODH Inhibitor -
HY-132170
DSM502DHODH Inhibitor
Actividad biológica
Descripciòn
In Vitro
DHODH-IN-23 (Compound A; 72 h) inhibits acute myeloid leukemia cells proliferation[1].
DHODH-IN-23 (0.1-3 μM; 72 h) induces CDllb expression in THP-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
-
Cell Line:U937, HL-60, THP-1, KG-1 and MV411
-
Concentration:
-
Incubation Time:72 h
-
Result:Inhibited cell growth with GI50s of 2.4, 2.5, 2.5, 3.5 and 7.6 μM against U937, THP-1, MV411 HL-60 and KG-1, respectively.
-
Cell Line:THP-1 cells
-
Concentration:72 h
-
Incubation Time:0.1, 1 and 3 μM
-
Result:Induced CDllb mRNA expression.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:MV411 mouse xenograft model[1]
-
Dosage:30 mg/kg
-
Administration:Oral administration, twice daily for 21 days
-
Result:Demonstrated significant anti-tumor activity both as a single agent and in combination with Cytarabine (HY-13605) at 20 mg/kg with tumor growth inhibitions of 37 and 73% respectively.
Chemical Information
-
No. CAS 1346705-53-0
-
Appearance Solid
-
Peso molecular 441.88
-
Fòrmula C24H21ClFNO4
-
Color White to off-white
-
SMILES
O=C(C1=C(C(NC2=C(C=C(C3=CC=CC(OCCCC)=C3)C=C2Cl)F)=O)C=CC=C1)O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (282.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (272 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2631 mL | 11.3153 mL | 22.6306 mL | 56.5764 mL |
| 5 mM | 0.4526 mL | 2.2631 mL | 4.5261 mL | 11.3153 mL | |
| 10 mM | 0.2263 mL | 1.1315 mL | 2.2631 mL | 5.6576 mL | |
| 15 mM | 0.1509 mL | 0.7544 mL | 1.5087 mL | 3.7718 mL | |
| 20 mM | 0.1132 mL | 0.5658 mL | 1.1315 mL | 2.8288 mL | |
| 25 mM | 0.0905 mL | 0.4526 mL | 0.9052 mL | 2.2631 mL | |
| 30 mM | 0.0754 mL | 0.3772 mL | 0.7544 mL | 1.8859 mL | |
| 40 mM | 0.0566 mL | 0.2829 mL | 0.5658 mL | 1.4144 mL | |
| 50 mM | 0.0453 mL | 0.2263 mL | 0.4526 mL | 1.1315 mL | |
| 60 mM | 0.0377 mL | 0.1886 mL | 0.3772 mL | 0.9429 mL | |
| 80 mM | 0.0283 mL | 0.1414 mL | 0.2829 mL | 0.7072 mL | |
| 100 mM | 0.0226 mL | 0.1132 mL | 0.2263 mL | 0.5658 mL |
DHODH-IN-23 Related Classifications
HY-153112 Related Classifications
Powered by Bioz