FPL 66564
FPL 66564 is a short-acting angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5.7 nM against rabbit ACE. FPL 66564 inhibits ACE activity at the functional level and is hydrolyzed in human blood into inactive hydrophilic metabolites. FPL 66564 modulates angiotensin I-induced pressor responses in anesthetized rats, and its effects rapidly return to baseline after cessation of intravenous infusion. FPL 66564 can be used for research on cardiovascular regulation related to critical illness.
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- No. CAS: 140369-78-4
- Fòrmula: C8H14O4S2
- Peso molecular:238.32
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
ACE 5.7 nM (IC50) |
In Vitro
FPL 66564 is degraded in human blood with a half-life of 14 minutes to form inactive, small hydrophilic products[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat (anesthetized with urethane)[2]
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Dosage:100 nmol/kg/min; 300 nmol/kg/min; 1000 nmol/kg/min
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Administration:i.v.; continuous infusion
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Result:Achieved rapid equilibrium of pressor response inhibition, followed by a sustained plateau.
Maintained ~90-95% inhibition of pressor response during infusion at 1000 nmol/kg/min dose.
Maintained ~75-80% inhibition during infusion at 300 nmol/kg/min dose.
Maintained ~60-65% inhibition during infusion at 100 nmol/kg/min dose.
Rapidly dissipated inhibitory effect on cessation of infusion, with all groups returning to near-baseline levels of inhibition (≤25%) by 60 minutes post-infusion.
Chemical Information
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No. CAS 140369-78-4
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Peso molecular 238.32
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Fòrmula C8H14O4S2
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SMILES
SC[C@@H](C)C(O[C@H](C(O)=O)CSC)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FPL 66564 Related Classifications
HY-182445 Related Classifications
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