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Referencia número: HY-172195

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FS-694

FS-694, a chemical probe, is the inhibitor for p38α with an IC₅₀ of 0.2 nM. FS-694 inhibits the TNFα release in human whole blood with an IC₅₀ of 35.0 nM.

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No. CAS: 1417404-27-3
Fòrmula: C₃₅H₃₃FN₄O₄
Peso molecular:592.66

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

FS-694 Chemical Structure

No. CAS: 1417404-27-3

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Bioz

Actividad biológica

Descripciòn

FS-694, a chemical probe, is the inhibitor for p38α with an IC₅₀ of 0.2 nM. FS-694 inhibits the TNFα release in human whole blood with an IC₅₀ of 35.0 nM^[1].

Ver todos los productos específicos de isoformas p38 MAPK :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	4.3 nM Compound: 2	Inhibition of NanoBRET kinase tracer K4 binding to full-length human C-terminal NanoLuc-tagged p38alpha MAPK expressed in HEK293T cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay Inhibition of NanoBRET kinase tracer K4 binding to full-length human C-terminal NanoLuc-tagged p38alpha MAPK expressed in HEK293T cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay	[PMID: 32462866]
Sf9	IC₅₀	4 nM Compound: 2	Inhibition of recombinant human full-length N-terminal GST-tagged p38alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by ADP-glo Inhibition of recombinant human full-length N-terminal GST-tagged p38alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by ADP-glo	[PMID: 32462866]

Chemical Information

No. CAS 1417404-27-3
Peso molecular 592.66
Fòrmula C₃₅H₃₃FN₄O₄
SMILES

FC(C=C1)=C(NC(C2=CC=CC=C2)=O)C=C1NC3=CC(CCC(C=CC(C(NCCN4CCOCC4)=O)=C5)=C5C6=O)=C6C=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Walter NM, et al., Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine. J Med Chem. 2017 Oct 12;60(19):8027-8054. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
Chemical Information
Pureza y Documentación
Referencias