Igf1r - insulin-like growth factor 1 receptor Gene

Also Known as Igfr1; JTK13; IGFIRC; IGF-1 receptor

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25718

About Igf1r

Primary_assembly 1: 121,550,743-121,831,777 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 276 orthologues, 54 paralogues and is associated with 88 phenotypes. Biased expression in Adrenal (RPKM 154.5), Kidney (RPKM 119.) and 9 other tissues.

Summary

Enables G-protein alpha-subunit binding activity; Insulin Receptor substrate binding activity; and insulin-like growth factor-activated receptor activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and nervous system development. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); cryptorchidism; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney Cancer (multiple); liver disease (multiple); and nervous system Cancer (multiple). Orthologous to human IGF1R (Insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Igf1r Products (2)

mRNA Protein Name
NM_001414181.1 NP_001401110.1 insulin-like growth factor 1 receptor isoform 1 precursor
NM_052807.3 NP_434694.1 insulin-like growth factor 1 receptor isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
19764351 RGD
enables insulin receptor substrate binding IPI
IPI: Inferred from physical interaction
15272025 RGD
enables insulin-like growth factor receptor activity IDA
IDA: Inferred from direct assay
16909201 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11423532 RGD
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
16909201 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
15272025 RGD
Biological Process GO Annotation Evidence Referencias Source
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
16845384 RGD
involved in cardiac atrium development IEP
IEP: Inferred from expression pattern
15486038 RGD
involved in cellular response to aldosterone IEP
IEP: Inferred from expression pattern
22173225 RGD
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
8579617 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
19853640 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
10650946 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
20633551 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
20013160 RGD
involved in cellular response to insulin-like growth factor stimulus IEP
IEP: Inferred from expression pattern
23349896 RGD
involved in cellular response to insulin-like growth factor stimulus IPI
IPI: Inferred from physical interaction
12837295 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
21854769 RGD
involved in cellular response to progesterone stimulus IEP
IEP: Inferred from expression pattern
19853640 RGD
involved in cellular response to testosterone stimulus IEP
IEP: Inferred from expression pattern
10650946 RGD
involved in cellular response to transforming growth factor beta stimulus IPI
IPI: Inferred from physical interaction
12837295 RGD
involved in cellular response to zinc ion starvation IEP
IEP: Inferred from expression pattern
21893222 RGD
involved in cellular senescence IEP
IEP: Inferred from expression pattern
19862643 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
23397157 RGD
involved in cerebellum development IMP
IMP: Inferred from mutant phenotype
21443795 RGD
involved in dendritic spine maintenance IGI
IGI: Inferred from genetic interaction
19406747 RGD
involved in establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
16845384 RGD
involved in estrous cycle IMP
IMP: Inferred from mutant phenotype
17567960 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
22042446 RGD
involved in insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19406747 RGD
involved in negative regulation of cholangiocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
17531559 RGD
involved in negative regulation of hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
17531559 RGD
involved in negative regulation of muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19507001 RGD
involved in neuron projection development IDA
IDA: Inferred from direct assay
15567343 RGD
involved in positive regulation of DNA metabolic process IMP
IMP: Inferred from mutant phenotype
19507001 RGD
involved in positive regulation of axon regeneration IMP
IMP: Inferred from mutant phenotype
23349896 RGD
involved in positive regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
19507001 RGD
involved in positive regulation of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
15110779 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
25186839 RGD
involved in positive regulation of protein-containing complex disassembly IGI
IGI: Inferred from genetic interaction
19406747 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
21854769 RGD
involved in positive regulation of steroid hormone biosynthetic process IMP
IMP: Inferred from mutant phenotype
17023532 RGD
involved in response to L-glutamate IDA
IDA: Inferred from direct assay
18981172 RGD
involved in response to alkaloid IEP
IEP: Inferred from expression pattern
30240970 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
17645580 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
24239160 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
30240970 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
19008912 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
22265867 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
21266509 RGD
involved in response to vitamin E IEP
IEP: Inferred from expression pattern
17447016 RGD
Cellular Component GO Annotation Evidence Referencias Source
located in T-tubule IDA
IDA: Inferred from direct assay
23118311 RGD
located in axon IDA
IDA: Inferred from direct assay
23349896 RGD
located in caveola IDA
IDA: Inferred from direct assay
18022157 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
19862643 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Igf1r Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (50 - 160)

Furin-like

Furin-like: pfam00757 (174 - 329)

Recep_L_domain

Recep_L_domain: pfam01030 (352 - 467)

FN3

FN3: cd00063 (493 - 606)

FN3

FN3: cd00063 (611 - 655)

FN3

FN3: cd00063 (836 - 925)

PTKc_InsR_like

PTKc_InsR_like: cd05032 (993 - 1270)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1372 a.a.
Protein Preferred Names Protein Names

insulin-like growth factor 1 receptor

  • IGF-I receptor

  • insulin-like growth factor I receptor

  • type-I IGF receptor

Recombinant Igf1r Proteins

Referencia número Nombre del producto Accession Pureza
HY-P78724 IGF-I R Protein, Rat (HEK293, His) P24062 (E31-H936) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Referencia número Nombre del producto Efecto
Pureza Rare Diseases
HY-15656 Ceritinib Inhibitor 99.95% Yes
HY-15656A Ceritinib dihydrochloride Inhibitor 99.90% Yes
HY-B0025 Voglibose Inhibitor 98.0% Unkown
HY-15656AR Ceritinib dihydrochloride (Standard) Inhibitor / Unkown
HY-15656R Ceritinib (Standard) Inhibitor 99.72% Unkown
Inhibitory Antibodies (2)
Referencia número Nombre del producto Efecto
Pureza Rare Diseases
HY-P99165 Teprotumumab Inhibitor 99.46% Unkown
HY-P990084 Veligrotug 99.25% Unkown

Clinical Phase

Bioactive Molecules (8)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-15656B Ceritinib mesylate Inhibitor / Phase 4
HY-15494 Picropodophyllin 99.85% Phase 2
HY-10200 BMS-754807 Inhibitor 99.42% Phase 2
HY-19565 KW-2450 tosylate / Phase 2
HY-B0794 AZ7550 Inhibitor 97.09% Phase 1
HY-15749 XL228 Inhibitor 99.64% Phase 1
HY-13326 ASP3026 99.88% Phase 1
HY-113402B Gamma-glutamylcysteine ammonium / Phase 1
Inhibitory Antibodies (8)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-P99294 Ganitumab Inhibitor 96.00% Phase 3
HY-P99197 Figitumumab Inhibitor ≥99.0% Phase 3
HY-P99189 Cixutumumab Inhibitor 99.63% Phase 2
HY-P99284 Dalotuzumab 97.43% Phase 2
HY-P99218 Robatumumab Inhibitor 98.00% Phase 2
HY-P99712 Lonigutamab 95.00% Phase 2
HY-P99672 Istiratumab Inhibitor 98.45% Phase 2
HY-P991253 BIIB022 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (66)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-113402 Gamma-glutamylcysteine 98.53% Unkown
HY-116624 MAZ51 99.96% Unkown
HY-50866 NVP-AEW541 99.71% Unkown
HY-10262 BMS-536924 99.83% Unkown
HY-15609 AZD-3463 99.31% Unkown
HY-13203 NVP-TAE 226 99.77% Unkown
HY-N7922 Urolithin M5 Inhibitor 97.31% Unkown
HY-10252 NVP-ADW742 99.30% Unkown
HY-10253 AG1024 99.50% Unkown
HY-N0908 Ginsenoside Rg5 99.88% Unkown
HY-10524 GSK1904529A 99.03% Unkown
HY-Y1322 Triphenyl phosphate 99.67% Unkown
HY-113402A Gamma-glutamylcysteine TFA 96.68% Unkown
HY-N1990 Gypenoside XLIX 99.88% Unkown
HY-P5133 Synstatin (92-119) Inhibitor 97.61% Unkown
HY-P3226 JB-1 99.63% Unkown
HY-100349 SU4312 Inhibitor 99.74% Unkown
HY-B0794B AZ7550 Mesylate Inhibitor 98.70% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-135680 I-OMe-Tyrphostin AG 538 Inhibitor 98.03% Unkown
HY-18785 Indirubin Derivative E804 Inhibitor 98.54% Unkown
HY-113402R Gamma-glutamylcysteine (Standard) 98.14% Unkown
HY-145110 IGF-1R inhibitor-2 Inhibitor 98.07% Unkown
HY-156914 IGF-1R/SRC-IN-1 Inhibitor 99.86% Unkown
HY-177760 PrCP-7414 / Unkown
HY-125102 AZ12253801 Inhibitor / Unkown
HY-15656S Ceritinib-d7 Inhibitor 98.00% Unkown
HY-B0794A AZ7550 hydrochloride Inhibitor 98.66% Unkown
HY-113402AR Gamma-glutamylcysteine TFA (Standard) 95.17% Unkown
HY-15494R Picropodophyllin (Standard) 99.70% Unkown
HY-21291 SU-4313 Modulator 99.31% Unkown
HY-B0794S AZ7550-d5 Inhibitor / Unkown
HY-N6611 Chimaphilin Inhibitor 99.80% Unkown
HY-50866B NVP-AEW541 dihydrochloride / Unkown
HY-100038 AZD9362 Inhibitor / Unkown
HY-10252A cis-NVP-ADW742 Inhibitor / Unkown
HY-10438 BMS-577098 Inhibitor / Unkown
HY-108230 ALK-IN-12 Inhibitor / Unkown
HY-116059 EGFR-IN-199 Inhibitor / Unkown
HY-118046 GSK2163632A Inhibitor / Unkown
HY-13312A GTx-134 / Unkown
HY-15494S Picropodophyllin-d3 / Unkown
HY-15494S1 Picropodophyllin-d6 / Unkown
HY-162506 IGF-1R inhibitor-3 Inhibitor / Unkown
HY-167854 KW-2450 free base Inhibitor / Unkown
HY-169572 IGF-1R inhibitor-5 Inhibitor / Unkown
HY-169600 IGF-1R inhibitor-4 Inhibitor / Unkown
HY-17603A (E)-Belizatinib Inhibitor / Unkown
HY-177622 Cibrigirsen Inhibitor / Unkown
HY-177622A Cibrigirsen sodium Inhibitor / Unkown
HY-179732 PROTAC ALK degrader-4 / Unkown
HY-180972 PROTAC EML4-ALK Degrader-2 Inhibitor / Unkown
HY-182264 Masoprocol tetrapivalate Inhibitor / Unkown
HY-183292 SH-1092 Inhibitor / Unkown
HY-402309 IGF-1R modulator 1 Modulator / Unkown
HY-B0793G AZ-5104 (GMP) / Unkown
HY-E70730 INSR Recombinant Human Active Protein Kinase / Unkown
HY-RS06615 IGF1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06616 Igf1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06617 Igf1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100349A cis-SU4312 Inhibitor / Unkown
HY-14357 BMS 695735 Inhibitor / Unkown
HY-168616 CL-A3-7 Inhibitor / Unkown
HY-174654 Human IGF1R mRNA / Unkown
HY-174721 Human EGFR mRNA / Unkown
HY-W749516 Voglibose-13C3 Inhibitor / Unkown
Inhibitory Antibodies (2)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-P991134 Elegrobart Inhibitor 95.27% Unkown
HY-P991255 VRDN-002 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Igf1r NCBI NCBI:3480