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Cat. No.: HY-100038

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AZD9362

AZD9362 is a reversible, ATP-competitive and orally active small molecule inhibitor of IGF-1R and insulin receptor. AZD9362 inhibits the IGF-1R enzyme with an IC₅₀ of 14 nM. AZD9362 can enhance the anti-tumor effect of AZD5363 (HY-15431). AZD9362 can be used for the research of cancer, such as breast cancer.

For research use only. We do not sell to patients.

CAS No.: 1905412-80-7
Formula: C₂₄H₂₇ClN₈O₂
Molecular Weight:494.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AZD9362 Chemical Structure

CAS No.: 1905412-80-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	29 μM Compound: 28; AZD9362	Inhibition of human ERG expressed in CHOK1 cells after 6 mins by electrophysiology assay Inhibition of human ERG expressed in CHOK1 cells after 6 mins by electrophysiology assay	[PMID: 27078757]

In Vivo

AZD9362 (25 mg/kg, p.o.) enhances the anti-tumor effect of AZD5363 (HY-15431) in MCF-7/LTED cells and MCF-7 xenografts in ovariectomized mice devoid of estrogen supplementation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1905412-80-7
Molecular Weight 494.98
Formula C₂₄H₂₇ClN₈O₂
SMILES

CC1=NN(C2CCN(C([C@H](O)C)=O)CC2)C(C)=C1NC3=NC=C(Cl)C(C4=C5C=CC=CN5N=C4)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fox EM, et al. Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation. Breast Cancer Res. 2013;15(4):R55. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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