2. Protein Tyrosine Kinase/RTK
  3. IGF-1R Insulin Receptor
  4. AZD9362

AZD9362 is a reversible, ATP-competitive and orally active small molecule inhibitor of IGF-1R and insulin receptor. AZD9362 inhibits the IGF-1R enzyme with an IC50 of 14 nM. AZD9362 can enhance the anti-tumor effect of AZD5363 (HY-15431). AZD9362 can be used for the research of cancer, such as breast cancer.

For research use only. We do not sell to patients.

AZD9362

AZD9362 Chemical Structure

CAS No. : 1905412-80-7

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AZD9362 Related Antibodies

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Description

AZD9362 is a reversible, ATP-competitive and orally active small molecule inhibitor of IGF-1R and insulin receptor. AZD9362 inhibits the IGF-1R enzyme with an IC50 of 14 nM. AZD9362 can enhance the anti-tumor effect of AZD5363 (HY-15431). AZD9362 can be used for the research of cancer, such as breast cancer[1].

Cellular Effect
Cell Line Type Value Description References
CHO-K1 IC50
29 μM
Compound: 28; AZD9362
Inhibition of human ERG expressed in CHOK1 cells after 6 mins by electrophysiology assay
Inhibition of human ERG expressed in CHOK1 cells after 6 mins by electrophysiology assay
[PMID: 27078757]
In Vivo

AZD9362 (25 mg/kg, p.o.) enhances the anti-tumor effect of AZD5363 (HY-15431) in MCF-7/LTED cells and MCF-7 xenografts in ovariectomized mice devoid of estrogen supplementation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

494.98

Formula

C24H27ClN8O2
CAS No.
SMILES

CC1=NN(C2CCN(C([C@H](O)C)=O)CC2)C(C)=C1NC3=NC=C(Cl)C(C4=C5C=CC=CN5N=C4)=N3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AZD9362 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD93621905412-80-7AZD 9362AZD-9362IGF-1RInsulin ReceptorInsulin-like growth factor-1 receptorinsulin receptorAZD5363anti-tumorbreast cancerInhibitorinhibitorinhibit

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