HAA-09
HAA-09 is an orally active and potent anti-influenza agent, targeting the influenza PB2_cap binding domain. HAA-09 displays potent anti-influenza A virus activity, with an EC50 of 0.03 μM. HAA-09 shows polymerase inhibition, with an IC50 of 0.06±0.004 μM. HAA-09 blocks virus replication without causing obvious cytotoxicity.
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- No. CAS: 1422051-33-9
- Fòrmula: C17H18F2N6O2
- Peso molecular:376.36
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
IC50: 0.06±0.004 μM (polymerase); EC50: 0.03 μM (influenza A virus)[1]
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Cell Line
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Type | Value | Description | References |
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| A549 | CC50 |
>100 μM
Compound: HAA-09
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Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by CCK-8 method
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by CCK-8 method
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[PMID: 36773549] |
HAA-09 (0-25 mg/kg; Orally, BID) exhibits anti-influenza virus efficacy in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/C mice[1]
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Dosage:40 mg/kg
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Administration:Orally, QD (once daily) for consecutive 3 days
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Result:Demonstrated a favorable safety profile when orally administrated in healthy mice.
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Animal Model:Female BALB/c mice (6–8 weeks)[1]
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Dosage:12.5, 25 mg/kg
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Administration:Orally, BID (twice daily) starting 48 h post infection for 9 days
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Result:Demonstrated in vivo therapeutic efficacy (85.7% survival observed at the day 15 post infection).
Chemical Information
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No. CAS 1422051-33-9
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Peso molecular 376.36
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Fòrmula C17H18F2N6O2
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SMILES
CC(C)(N(NC1=C(C=NC(C2=CNC3=C2C=C(C=N3)F)=N1)F)CC(O)=O)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HAA-09 Related Classifications
HY-149263 Related Classifications
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