Idrocilamide
Idrocilamide (LCB29) exhibits a muscle relaxing effect, that inhibits muscle twitch, tetanic tension, K+-induced as well as voltage clamp-induced contraction of rat soleus muscle fibers. Idrocilamide is also a caffeine antagonist, inhibiting the breakdown and biotransformation of caffeine.
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- No. CAS: 6961-46-2
- Fòrmula: C11H13NO2
- Peso molecular:191.23
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 6961-46-2
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Peso molecular 191.23
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Fòrmula C11H13NO2
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SMILES
O=C(NCCO)/C=C/C1=CC=CC=C1
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Synonyms
LCB29
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Two-electrode voltage clamp in Xenopus oocytes
Two-electrode voltage clamp measures whole-oocyte membrane current from Xenopus oocytes expressing exogenous ion channels, receptors, or transporters; one intracellular microelectrode senses membrane voltage, and the second injects current so the amplifier can hold the membrane at command voltages while recording the compensating current as the functional readout. The method is suited to Xenopus oocytes because their large size supports microinjection and intracellular electrode impalement, but the large membrane area can limit voltage-clamp speed and accuracy, especially for large or fast currents.
Pureza y Documentación
Referencias
[1]. Brazier JL, et al. Inhibition by idrocilamide of the disposition of caffeine. Eur J Clin Pharmacol. 1980 Jan;17(1):37-43. [Content Brief]
[2]. Bouron A, et al., The direct depressant effect of LCB29 (idrocilamide) on mechanical tension of rat soleus muscle fibers. Can J Physiol Pharmacol. 1990 Dec;68(12):1503-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Idrocilamide Related Classifications
HY-108381 Related Classifications
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