KOTX1
Based on 1 publication(s) in Google Scholar
KOTX1 is an orally active and selective ALDH1A3 inhibitor. KOTX1 improves glucose tolerance, insulin secretion and blood sugar levels in diabetic mouse models.
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- Pureza: 98.94%
- No. CAS: 1788963-83-6
- Fòrmula: C17H16FN3O2
- Peso molecular:313.33
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-diabetic Compound Library
HY-L040
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Orally Active Compound Library
HY-L061
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Glutamine Metabolism Compound Library
HY-L064
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Anti-Cancer Metabolism Compound Library
HY-L083
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Cancer Stem Cells Compound Library
HY-L135
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Metabolic Enzyme Compound Library
HY-L146
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Highly Selective Inhibitors Library
HY-L158
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) KOTX1
More
Actividad biológica
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ALDH1A3 |
KOTX1 (0-1 μM) has an IC50 of 5.14 nM for ALDH1A3 in A375 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male db/db mice aged 5 months old[1]
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Dosage:40 mg/kg
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Administration:Oral gavage (i.g.); 4 weeks
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Result:Improved glucose tolerance in mice.
Increased plasma insulin levels.
Did not change body weight and food intake.
Chemical Information
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No. CAS 1788963-83-6
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Appearance Solid
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Peso molecular 313.33
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Fòrmula C17H16FN3O2
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Color White to off-white
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SMILES
O=C(C1=C(CC)C=NC=C1)NC2=C(F)C=C(NC(CC3)=O)C3=C2
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Synonyms
MBE1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Carbohydr Polym
A sulfated manno-glucuronan ameliorates β-cell dysfunction in type 2 diabetes by targeting ALDH1A3. [Abstract]2026 Jun 15:382:125227. PMID: 42002316
Solvente y solubilidad
DMSO : 125 mg/mL (398.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1915 mL | 15.9576 mL | 31.9152 mL | 79.7881 mL |
| 5 mM | 0.6383 mL | 3.1915 mL | 6.3830 mL | 15.9576 mL | |
| 10 mM | 0.3192 mL | 1.5958 mL | 3.1915 mL | 7.9788 mL | |
| 15 mM | 0.2128 mL | 1.0638 mL | 2.1277 mL | 5.3192 mL | |
| 20 mM | 0.1596 mL | 0.7979 mL | 1.5958 mL | 3.9894 mL | |
| 25 mM | 0.1277 mL | 0.6383 mL | 1.2766 mL | 3.1915 mL | |
| 30 mM | 0.1064 mL | 0.5319 mL | 1.0638 mL | 2.6596 mL | |
| 40 mM | 0.0798 mL | 0.3989 mL | 0.7979 mL | 1.9947 mL | |
| 50 mM | 0.0638 mL | 0.3192 mL | 0.6383 mL | 1.5958 mL | |
| 60 mM | 0.0532 mL | 0.2660 mL | 0.5319 mL | 1.3298 mL | |
| 80 mM | 0.0399 mL | 0.1995 mL | 0.3989 mL | 0.9974 mL | |
| 100 mM | 0.0319 mL | 0.1596 mL | 0.3192 mL | 0.7979 mL |
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