Lanolin
Based on 1 Customer Validation
Lanolin is a yellow fat that can be extracted from wool. Lanolin can be used as a skin moisturizer and applied topically to relieve nipple pain and chapping during lactation.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 8006-54-0
- Fòrmula: C54H84N16O21
- Peso molecular:1293.34
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-N1446
Oleic acidMonounsaturated Fatty Acid -
HY-B2235
LecithinEndogenous Metabolite -
HY-B2235B
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L-α-Lecithin (egg yolk), 75%Biochemical Reagent -
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Propane-1,2,3-triyl tripalmitateGlycerol Tristearate Lymphatic Transport Promoter -
HY-N0322
Cholesterol (from animal)ERRα Agonist -
HY-N0729
Linoleic acidHuman Endogenous Metabolite -
HY-N1446R
Oleic acid (Standard)Monounsaturated Fatty Acid -
HY-N2041
Myristic acidEndogenous Metabolite -
HY-Y0366
Lauric acidMiddle Chain-free Fatty Acid -
HY-N0322R
Cholesterol (Standard)
Actividad biológica
Descripciòn
In Vitro
Lanolin, when mixed with olive oil to make an ointment, shows significant protective effects against dermatitis and cancer caused by mineral oil. Its protective effects against tar, however, vary with dosage: it is effective at low doses but may promote cancer at high doses[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Transgenic Fischer 344 rats (Rattus norvegicus), pups aged 7 to 17 days at presentation, with naturally occurring ringtail due to low relative humidity[3]
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Dosage:Lanolin in the form of ointment
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Administration:Applied to tails; once daily; 6 days
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Result:Was well-tolerated by pups, with no rejection by dams.
Led to a higher proportion of rats with better tail health compared to the control group on day 7.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 8006-54-0
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Appearance Oil
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Peso molecular 1293.34
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Fòrmula C54H84N16O21
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Color Light yellow to yellow
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SMILES
[Lanolin]
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Structure Classification
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Initial Source
sheep's wool
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
In Vitro:
DMSO : 10 mg/mL (7.73 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (1.93 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (1.93 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Lanolin. 2025 Jan 15. [Content Brief]
[2]. Twort CC, et al. The Utility of Lanolin as a Protective Measure against Mineral-Oil and Tar Dermatitis and Cancer. J Hyg (Lond). 1935 Feb;35(1):130-49. [Content Brief]
[3]. Taylor DK, et al. Lanolin as a treatment option for ringtail in transgenic rats. J Am Assoc Lab Anim Sci. 2006 Jan;45(1):83-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7732 mL | 3.8660 mL | 7.7319 mL | 19.3298 mL |
| 5 mM | 0.1546 mL | 0.7732 mL | 1.5464 mL | 3.8660 mL |
Lanolin Related Classifications
HY-N7074 Related Classifications
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