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Referencia número: HY-123737

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MK-8133

MK-8133 is an orexin-2 receptor antagonist. MK-8133 can be used in the study of insomnia.

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No. CAS: 1431472-56-8
Fòrmula: C₂₃H₂₁N₅O₂
Peso molecular:399.45

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

MK-8133 Chemical Structure

No. CAS: 1431472-56-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
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Actividad biológica

Descripciòn

MK-8133 is an orexin-2 receptor antagonist. MK-8133 can be used in the study of insomnia^[1].

IC₅₀ & Target

OX₂ Receptor

Ver todos los productos específicos de isoformas Orexin Receptor (OX Receptor) :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	28 nM Compound: 6b	Antagonist activity against human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay Antagonist activity against human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay	[PMID: 25981685]
CHO-K1	IC₅₀	4900 nM Compound: 6b	Antagonist activity against human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay Antagonist activity against human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intercellular Ca2+ mobilization by FLIPR assay	[PMID: 25981685]

Chemical Information

No. CAS 1431472-56-8
Peso molecular 399.45
Fòrmula C₂₃H₂₁N₅O₂
SMILES

N#CC1=CC(O[C@H]2CN(C(C3=CC=CC=C3C4=NC=CC=N4)=O)[C@H](C)CC2)=NC=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Kuduk SD, et al. Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2488-92. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Calculadora de dilución

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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MK-8133

Ver todos los productos específicos de isoformas Orexin Receptor (OX Receptor)

Actividad biológica

Descripciòn

IC50 & Target

Cellular Effect

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

MK-8133 Related Classifications

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