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Referencia número: HY-189374

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OAT-IN-2

OAT-IN-2 is an ornithine aminotransferase (hOAT) inhibitor. OAT-IN-2 is used in the research of hepatocellular carcinoma.

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No. CAS: 3057206-96-6
Fòrmula: C₇H₉F₂NO₂
Peso molecular:177.15

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

OAT-IN-2 Chemical Structure

No. CAS: 3057206-96-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Protocolo (1)
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

OAT-IN-2 is an ornithine aminotransferase (hOAT) inhibitor. OAT-IN-2 is used in the research of hepatocellular carcinoma^[1].

In Vitro

OAT-IN-2 (Compound 5) is a time-dependent inhibitor of hOAT with a k_inact/K_I of 0.219 mM^-1 min^-1^[1].
OAT-IN-2 (2-18 equiv; 72 h) irreversibly inhibits hOAT, as no enzymatic activity was recovered after 72 h of dialysis^[1].
OAT-IN-2 forms a noncovalent, tight-binding adduct with hOAT^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

No. CAS 3057206-96-6
Peso molecular 177.15
Fòrmula C₇H₉F₂NO₂
SMILES

O=C([C@]12C[C@H](N)C[C@@]1([H])C2(F)F)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocolo

All Animals and Diseases

Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers^[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Devitt AN, et al. Design and Elucidation of a Strain-Relief-Driven Ring Opening Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3R,5R)-3-Amino-6,6-difluorobicyclo[3.1.0]hexane-1-carboxylic Acid. J Am Chem Soc. 2026 Aug 19;148(32):34916-34927.

Calculators

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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