Pleioside A
Pleioside A is a flavonoid glycoside with immunomodulatory activity that is found in the leaves of Pleioblastus amarus. Pleioside A exerts differential regulatory effects on adaptive immune lymphocyte proliferation by inhibiting mouse T cell proliferation and promoting B lymphocyte proliferation. Pleioside A can be used for research on adaptive immunity and immunomodulation.
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- No. CAS: 199925-44-5
- Fòrmula: C24H26O12
- Peso molecular:506.46
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Descripciòn
In Vitro
Pleioside A (compound 1) (40 μM; 48 h) inhibits ConA-induced mouse T cell proliferation[1].
Pleioside A (400 nM-40 μM; 48 h) significantly stimulates LPS (HY-D1056)-induced proliferation of mouse B lymphocytes, with a strong stimulatory effect observed at 40 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:mouse spleen cells
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Concentration:400 nM, 4 μM, 40 μM
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Incubation Time:48 h
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Result:Inhibited ConA-induced T cell proliferation in a concentration-dependent manner.
At 400 nM, 3H-TdR incorporation was 100.68 × 103 cpm.
At 4 μM, 3H-TdR incorporation decreased to 97.13 × 103 cpm.
At 40 μM, 3H-TdR incorporation decreased further to 90.18 × 103 cpm, representing a marked inhibition compared to the ConA positive control value of 107.24 × 103 cpm.\nStimulated LPS-induced B cell proliferation in a concentration-dependent manner.
At 400 nM, 3H-TdR incorporation was 30.97 × 103 cpm.
At 4 μM, 3H-TdR incorporation increased to 34.35 × 103 cpm.
At 40 μM, 3H-TdR incorporation rose further to 40.87 × 103 cpm, representing a marked stimulation compared to the LPS positive control value of 28.91 × 103 cpm.
Chemical Information
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No. CAS 199925-44-5
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Peso molecular 506.46
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Fòrmula C24H26O12
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SMILES
O=C1C2=C(O)C=C(OC)C=C2OC(C3=CC(OC)=C(C(OC)=C3)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pleioside A Related Classifications
HY-N21624 Related Classifications
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