LYN
LYN is a myristoylated Src-family tyrosine kinase prominently expressed in B lymphocytes, mast cells and myeloid cells. Uniquely among Src kinases, LYN plays dual, opposing roles: it initiates signaling by phosphorylating ITAM motifs of the B-cell receptor and Fc-epsilon receptor complexes, yet also terminates responses by phosphorylating ITIM motifs on inhibitory receptors such as CD22 and Fc-gamma receptor IIb, which recruit phosphatases like SHIP and SHP-1. Loss of LYN therefore paradoxically causes both impaired BCR signaling and autoimmune-like disease. LYN participates in mast cell degranulation and IgE-mediated allergy. Aberrant LYN expression is reported in chronic lymphocytic leukemia and B-cell lymphomas.
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LYN Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Fòrmula: Human
- Peso molecular: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
