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Referencia número: HY-181351

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PSN09

PSN09 is a blood-brain barrier-permeable agonist of PSAM⁴-GlyR and PSAM⁴-5-HT₃ receptors with high affinity. 18F-labeled PSN09 serves as a radiotracer for PET imaging in non-human primates.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₀H₁₈FN₃O
Peso molecular:335.37

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PSN09 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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Referencias
Calculators
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

5-HT₃ Receptor

Ver todos los productos específicos de isoformas 5-HT Receptor :

In Vitro

PSN09 potently binds to PSAM⁴-GlyR in transfected HEK-293 cells, with a K_i of 1.86 nM^[1].
PSN09 potently binds to PSAM⁴-5-HT₃ in transfected HEK-293 cells, with a K_i value of 5.67 nM^[1].
PSN09 (0.1-100 μM) potently activates PSAM⁴-GlyR in transfected HEK-293 cells, with an EC₅₀ of 8.3 nM^[1].
PSN09 (0.1-100 μM) potently activates PSAM⁴-5-HT₃ in transduced HEK-293 cells, with an EC₅₀ of 16.8 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PSN09 (1 mg/kg; i.v.; single dose) activates PSAM⁴-GlyR, thereby inducing neuronal inhibition in transduced rhesus monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Monkey transduced with PSAM⁴-GlyR (11-year-old male, Lenti-hSyn-PSAM⁴-GlyR injected into left amygdala)^[1]
Dosage:

1 mg/kg
Administration:

i.v.; single dose; administered 10 minutes before [¹⁸F]FDG injection
Result:

Did not significantly alter [¹⁸F]FDG arterial input functions.
Reduced MRGlu in the target transduced left amygdala by 19%, and decreased the target-to-mirror MRGlu ratio by 3%.

Chemical Information

Peso molecular 335.37
Fòrmula C₂₀H₁₈FN₃O
SMILES

FC1=CC=C(C=C1)COC2=NC3=CC4=C(C5CNCC4C5)C=C3N=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Nerella SG, et al. Discovery of Fluorinated Ultrapotent Chemogenetic Ligands for PET Imaging and Neural Modulation in Nonhuman Primates. J Med Chem. 2026;69(3):2773-2788. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- In Vitro
- In Vivo
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PSN09

Ver todos los productos específicos de isoformas 5-HT Receptor

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

PSN09 Related Classifications

HY-181351 Related Classifications