Sameridine
Sameridine (NIH-10908 free base) is a weak partial agonist of the μ-opioid receptor. Sameridine shows local anesthetic and analgesic properties. Sameridine has minimal respiratory depression at low doses, but can suppress ventilatory response at high doses. Sameridine can be used for the study of analgesic effect.
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- No. CAS: 143257-97-0
- Fòrmula: C21H34N2O
- Peso molecular:330.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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μ Opioid Receptor/MOR |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats (weighing 320-420 g)[1].
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Dosage:5 mg/mL (10 μL), 10 mg/mL (10 μL)
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Administration:Intrathecal injection, twice daily, five days a week, for two weeks.
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Result:No permanent motor impairment was observed in any group.
The dorsal horn neurons in the L1 segment of the spinal cord showed normal morphology, and no signs of neurotoxicity were found, such as edema, organelle damage, necrosis, or microglia.
Chemical Information
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No. CAS 143257-97-0
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Peso molecular 330.51
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Fòrmula C21H34N2O
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SMILES
O=C(C1(CCN(CC1)CCCCCC)C2=CC=CC=C2)N(CC)C
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Synonyms
NIH 10908 free base
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Mulroy MF, et al. Sameridine is safe and effective for spinal anesthesia: a comparative dose-ranging study with lidocaine for inguinal hernia repair. Anesth Analg. 1999 Apr;88(4):815-21. [Content Brief]
[2]. Osterlund A, et al. The effects on resting ventilation of intravenous infusions of morphine or sameridine, a novel molecule with both local anesthetic and opioid properties. Anesth Analg. 1999 Jan;88(1):160-5. [Content Brief]
[3]. Karlsten R, et al. Sameridine--intrathecal injection in the rat. Morphometric and morphologic analysis after chronic administration and effects on spinal cord blood flow. Acta Anaesthesiol Scand. 1999 May;43(5):573-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sameridine Related Classifications
HY-105525 Related Classifications
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