11 Results for "

NOTA-IMB-RGD

" in MedChemExpress (MCE) Product Catalog:
Products (11)

11 Results for "NOTA-IMB-RGD" in MCE Product Catalog:

NOTA-IMB-RGD
NOTA-IMB-RGD
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Referencia número: HY-175323
Target:  

Integrin PD-1/PD-L1

Áreas de investigación:  

Cancer

NOTA-IMB-RGD is a dual molecular probe targeting integrin αvβ3 and programmed death ligand-1 (PD-L1). NOTA-IMB-RGD blocks the PD-1/PD-L1 signaling pathway and integrin αvβ3-overexpressing tumor vasculature. NOTA-IMB-RGD is promising for research of solid tumors co-expressing PD-L1 and αvβ3 (e.g., glioma, breast cancer) .
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NOTA-Pep-1L
NOTA-Pep-1L
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Referencia número: HY-P10292
Target:  

Radionuclide-Drug Conjugates (RDCs) Interleukin Related

Áreas de investigación:  

Cancer

NOTA-Pep-1L specifically targets the IL13RA2 receptor for tumor imaging . NOTA-Pep-1L can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
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NOTA-AUNP-12
NOTA-AUNP-12
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Referencia número: HY-P11347
Target:  

PD-1/PD-L1

Áreas de investigación:  

Cancer

NOTA-AUNP-12 is a PD-L1 antagonist (IC50=2.24×10 −7 M). NOTA-AUNP-12 is promising for research of cancers (e.g., lung/esophageal cancers) .
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NK224
NK224
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Referencia número: HY-P10978
Target:  

PD-1/PD-L1

Áreas de investigación:  

Cancer

NK224 is a peptide-based radiotracer targeting human PD-L1, with dual-radionuclide ( 68Ga and 18F) labeling compatibility enabled by the NOTA chelator. NK224 exhibits high binding affinity to PD-L1, with an IC50 value of 2.45 nM. NK224 visualizes intrapatient tumor heterogeneity and dynamically monitors PD-L1 target occupancy during immunotherapy. NK224 can be used for the study of non-small cell lung cancer (NSCLC) .
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NOTA-COG1410
NOTA-COG1410
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Referencia número: HY-P10220
No. CAS: 2914099-35-5
Target:  

Radionuclide-Drug Conjugates (RDCs) TREM receptor

Áreas de investigación:  

Cancer

NOTA-COG1410 forms triggering receptor expressed on myeloid cells 2 (TREM2) targeting ligand. NOTA-COG1410 is capable of being labelled with 68Gallium ( 68Ga) for discovery and diagnosis of digestive system tumors through positron emission tomography/computed tomography (PET/CT). NOTA-COG1410 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .
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NOTA-FZCD-3
NOTA-FZCD-3
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Referencia número: HY-P11844
Target:  

Cathepsin Radionuclide-Drug Conjugates (RDCs)

Áreas de investigación:  

Cancer

NOTA-FZCD-3 is a NOTA (HY-134418)-labeled FZCD-3 polypeptide precursor that targets cathepsin D (CTSD) with a KD of 0.65 μM. NOTA-FZCD-3 binds specifically to the active site of CTSD, exhibits rapid in vivo clearance properties, and remains stable in blood for more than 2 h. NOTA-FZCD-3 can be used in studies monitoring CTSD-positive tumors .
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NP1
NP1
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Referencia número: HY-P11859
Target:  

ROR Radionuclide-Drug Conjugates (RDCs)

Áreas de investigación:  

Cancer

NP1 is a NOTA-chelated linear precursor based on the ROR1-targeting peptide. After labeling with [ 18F]AlF, NP1 yields [ 18F]AlF-NP1, a PET imaging probe with excellent ROR1 specificity (KD = 141.7 nM), rapid tumor uptake and high target-to-background ratio, which is suitable for non-invasive visualization of various ROR1-overexpressing tumors .
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NOTA-MAL-Cys39-Exendin-4
NOTA-MAL-Cys39-Exendin-4
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Referencia número: HY-P11945
Target:  

GLP Receptor

Áreas de investigación:  

Metabolic Disease Cancer

NOTA-MAL-Cys39-Exendin-4 is an imaging agent and radiotracer precursor targeting GLP-1R. NOTA-MAL-Cys39-Exendin-4 binds specifically to GLP-1R and is rapidly cleared by the liver and spleen during the blood pool phase. NOTA-MAL-Cys39-Exendin-4 can be efficiently radiolabeled with gallium-68 to form a stable radiotracer with high radiochemical purity. NOTA-MAL-Cys39-Exendin-4 is applicable to research related to insulinomas .
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NOTA-cRY9M
NOTA-cRY9M
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Referencia número: HY-P11852
Target:  

FGFR

Áreas de investigación:  

Cancer

NOTA-cRY9M is a reagent targeting FGFR1 with a Kd value of 58 nM, and exhibits subtype selectivity for FGFR2-4. When radiolabeled as [ 68Ga]Ga-NOTA-cRY9M, it functions as a stabilizer, imaging contrast enhancer, and tumor-targeting agent, and accumulates in FGFR1-positive non-small cell lung cancer xenograft models. NOTA-cRY9M can be used in studies related to non-small cell lung cancer .
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NOTA-Octreotide
NOTA-Octreotide
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Referencia número: HY-P0036D
No. CAS: 1427427-01-7
Target:  

Drug Derivative Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor Apoptosis

Áreas de investigación:  

Cancer

NOTA‑Octreotide is a selective SSTR2‑targeting PET tracer. NOTA‑Octreotide binds specifically to SSTR2 and accumulates in SSTR2‑expressing tissues. NOTA‑Octreotide enables effective imaging of somatostatin receptor‑positive tumors in mice and shows high specific uptake in SSTR2‑expressing organs in healthy rats. NOTA-Octreotide can be used for PET imaging investigation of neuroendocrine tumors. .
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NOTA-Asp2-αvβ6L
NOTA-Asp2-αvβ6L
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Referencia número: HY-P11596
No. CAS: 3107808-75-0
Target:  

Integrin

Áreas de investigación:  

Cancer

NOTA-Asp2-αvβ6L is an integrin αvβ6 binder with selective accumulation in αvβ6-positive pancreatic cancer cells and tumors. NOTA-Asp2-αvβ6L can be used as a PET/CT tracer for imaging pancreatic ductal adenocarcinoma (PDAC) .
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