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Referencia número: HY-P10978

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NK224

NK224 is a peptide-based radiotracer targeting human PD-L1, with dual-radionuclide (⁶⁸Ga and ¹⁸F) labeling compatibility enabled by the NOTA chelator. NK224 exhibits high binding affinity to PD-L1, with an IC₅₀ value of 2.45 nM. NK224 visualizes intrapatient tumor heterogeneity and dynamically monitors PD-L1 target occupancy during immunotherapy. NK224 can be used for the study of non-small cell lung cancer (NSCLC).

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₁₀₄H₁₄₅N₂₅O₂₉S
Peso molecular:2241.48

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

NK224 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

Chemical Information

Peso molecular 2241.48
Fòrmula C₁₀₄H₁₄₅N₂₅O₂₉S
Sequence

cyclo-(Ac-Tyr-NMeAla-Asn-Pro-His-Glu-Hyp-Trp-Ser-{TrpNHOAc}-NMeNle-NMeNle-Lys-Cys)-Gly-NH2-NOTA
Sequence Shortening

cyclo-{Ac-Y-{NMeAla}-NPHE-{Hyp}--{TrpNHOAc}-WS-{NMeNle-NMeNle}-KC}-G-NH2-NOTA
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhao L, et al. 68Ga-NK224 PET/CT for Noninvasive Evaluation of PD-L1 Expression and Intertumor Heterogeneity: A Translational Exploratory Study. Clin Cancer Res. 2025 Jul 15;31(14):2989-3001. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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