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United States

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Referencia número: HY-174978

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SK60

SK60 is a dimethylated derivative of GSK321 (HY-18948) with low nanomolar potency and high selectivity for IDH1R132H (IC₅₀ = 14.5 nM). SK60 can be used as a tracer for brain imaging with the fluorescent label [¹⁸F].

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₈H₂₈FN₅O₂
Peso molecular:485.55

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SK60 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Isocitrate Dehydrogenase (IDH) :

IDH1
IDH2

Chemical Information

Peso molecular 485.55
Fòrmula C₂₈H₂₈FN₅O₂
SMILES

CC1=CC=CC(NC(C2=NN(C3=C2CN(CC3(C)C)C(C4=CC=CN4)=O)CC5=CC=C(C=C5)F)=O)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Sarandeep Kau, et al., From Inhibitors to PET: SAR-Based Development of [18F]SK60 for mIDH1 Imaging. J. Med. Chem. 2025, 68, 13, 13750–13771.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
Chemical Information
Pureza y Documentación
Referencias

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SK60

Ver todos los productos específicos de isoformas Isocitrate Dehydrogenase (IDH)