Trimethylacetaldehyde
Based on 1 Customer Validation
Trimethylacetaldehyde (Pivalic aldehyde; Pivalaldehyde) is an inhibitor of E. coli betaine aldehyde dehydrogenase (ALDH) with a Ki of 4.5 mM. Trimethylacetaldehyde serves as a substrate for Drosophila melanogaster alcohol dehydrogenase (AdhS), undergoing oxidation and disproportionation reactions with the release of NADH, and also forms an inactive binary enzyme-aldehyde complex via a compulsory ordered reaction mechanism.
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- No. CAS: 630-19-3
- Fòrmula: C5H10O
- Peso molecular:86.13
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Almacenamiento:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
Trimethylacetaldehyde (100 mM) competitively inhibits purified betaine aldehyde dehydrogenase from Escherichia coli MC4100 (pFF423), with an apparent inhibition constant of 4.5 mM, and reduces the enzyme activity to 11% of that in the control group at a concentration of 100 mM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 630-19-3
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Appearance Liquid (Density: 0.7821 g/cm3)
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Peso molecular 86.13
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Fòrmula C5H10O
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Color Colorless to light yellow
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SMILES
O=CC(C)(C)C
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Synonyms
Pivalic aldehyde; Pivalaldehyde
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvente y solubilidad
In Vitro:
DMSO : 200 mg/mL (2322.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (466 KB)
- English - EN (466 KB)
- Français - FR (466 KB)
- Deutsch - DE (466 KB)
- Norwegian - NO (466 KB)
- Español - ES (466 KB)
- Swedish - SV (466 KB)
- Italian - IT (466 KB)
- Korean - KR (466 KB)
- Portuguese - PT (466 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Winberg JO, et al. Drosophila melanogaster alcohol dehydrogenase: mechanism of aldehyde oxidation and dismutation. The Biochemical journal. 1998 Feb 01;329 ( Pt 3)(Pt 3):561-70. [Content Brief]
[2]. Falkenberg P, et al. Purification and characterization of osmoregulatory betaine aldehyde dehydrogenase of Escherichia coli. Biochimica et biophysica acta. 1990 Jun 20;1034(3):253-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 11.6104 mL | 58.0518 mL | 116.1036 mL | 290.2589 mL |
| 5 mM | 2.3221 mL | 11.6104 mL | 23.2207 mL | 58.0518 mL | |
| 10 mM | 1.1610 mL | 5.8052 mL | 11.6104 mL | 29.0259 mL | |
| 15 mM | 0.7740 mL | 3.8701 mL | 7.7402 mL | 19.3506 mL | |
| 20 mM | 0.5805 mL | 2.9026 mL | 5.8052 mL | 14.5129 mL | |
| 25 mM | 0.4644 mL | 2.3221 mL | 4.6441 mL | 11.6104 mL | |
| 30 mM | 0.3870 mL | 1.9351 mL | 3.8701 mL | 9.6753 mL | |
| 40 mM | 0.2903 mL | 1.4513 mL | 2.9026 mL | 7.2565 mL | |
| 50 mM | 0.2322 mL | 1.1610 mL | 2.3221 mL | 5.8052 mL | |
| 60 mM | 0.1935 mL | 0.9675 mL | 1.9351 mL | 4.8376 mL | |
| 80 mM | 0.1451 mL | 0.7256 mL | 1.4513 mL | 3.6282 mL | |
| 100 mM | 0.1161 mL | 0.5805 mL | 1.1610 mL | 2.9026 mL |
Trimethylacetaldehyde Related Classifications
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