VU0546110
Based on 1 Customer Validation
VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, with IC50s of 1.287 μM (SLO3) and 59.80 μM (SLO1) in HEK293 cells, respectively. VU0546110 blocks heterologous SLO3 currents and endogenous K+ currents in human sperm. VU0546110 halts sperm hyperpolarization, induced acrosome reaction, and hyper-activated motility. VU0546110 has contraceptive potential.
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- Pureza: 98.47%
- No. CAS: 1421523-00-3
- Fòrmula: C24H31NO4S2
- Peso molecular:461.64
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
1.287 μM (SLO3), 59.80 μM (SLO1)[1]
VU0546110 (10 μM) blocks the K+ current in human sperm at intracellular free Ca2+ concentrations of 0-50 µM[1].
VU0546110 (2.5 μM) inhibits the hyperpolarized membrane potential at pH 8.0 in human spermatozoa[1].
VU0546110 (2.5-10 μM) inhibits the hyperactivated motility and Ca2+ ionophore A23187 (HY-N6687) or progesterone (HY-N0437) induced acrosome reaction in human sperm[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1421523-00-3
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Appearance Solid
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Peso molecular 461.64
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Fòrmula C24H31NO4S2
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Color White to off-white
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SMILES
O=C(CC1=CC=C(S(=O)(C(C)C)=O)C=C1)N2CCC(CC2)CSC3=CC=C(C=C3)OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (216.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1662 mL | 10.8310 mL | 21.6619 mL | 54.1548 mL |
| 5 mM | 0.4332 mL | 2.1662 mL | 4.3324 mL | 10.8310 mL | |
| 10 mM | 0.2166 mL | 1.0831 mL | 2.1662 mL | 5.4155 mL | |
| 15 mM | 0.1444 mL | 0.7221 mL | 1.4441 mL | 3.6103 mL | |
| 20 mM | 0.1083 mL | 0.5415 mL | 1.0831 mL | 2.7077 mL | |
| 25 mM | 0.0866 mL | 0.4332 mL | 0.8665 mL | 2.1662 mL | |
| 30 mM | 0.0722 mL | 0.3610 mL | 0.7221 mL | 1.8052 mL | |
| 40 mM | 0.0542 mL | 0.2708 mL | 0.5415 mL | 1.3539 mL | |
| 50 mM | 0.0433 mL | 0.2166 mL | 0.4332 mL | 1.0831 mL | |
| 60 mM | 0.0361 mL | 0.1805 mL | 0.3610 mL | 0.9026 mL | |
| 80 mM | 0.0271 mL | 0.1354 mL | 0.2708 mL | 0.6769 mL | |
| 100 mM | 0.0217 mL | 0.1083 mL | 0.2166 mL | 0.5415 mL |
VU0546110 Related Classifications
HY-164911 Related Classifications
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