Gck - glucokinase Gene

Also Known as Gk; GLK; HK4; HKIV; HXKP; Hlb62; MODY2; Gls006

Species: Mus musculus

Gene Type: protein coding
Gene ID: 103988

About Gck

Chromosome 11: 5,850,820-5,900,081 reverse strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 214 orthologues, 4 paralogues and is associated with 43 phenotypes. Biased expression in liver adult (RPKM 44.2), liver E18 (RPKM 7.5) and 1 other tissue.

Summary

Enables Glucokinase activity. Involved in calcium ion import; cellular glucose homeostasis; and positive regulation of Insulin secretion. Acts upstream of or within several processes, including carbohydrate phosphorylation; glucose homeostasis; and regulation of Insulin secretion. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; brain; musculoskeletal system; reproductive system; and sensory organ. Used to study familial hyperinsulinemic hypoglycemia 3; hyperinsulinemic hypoglycemia; maturity-onset diabetes of the young type 2; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (Glucokinase). [provided by Alliance of Genome Resources, Apr 2022]

Gck Products (2)

mRNA Protein Name
NM_001287386.1 NP_001274315.1 hexokinase-4 isoform 2
NM_010292.5 NP_034422.2 hexokinase-4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glucokinase activity IDA
IDA: Inferred from direct assay
141272 MGI
enables glucokinase activity IMP
IMP: Inferred from mutant phenotype
7510884 MGI
enables hexokinase activity IDA
IDA: Inferred from direct assay
8530440 MGI
enables hexokinase activity IMP
IMP: Inferred from mutant phenotype
23085254 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12931191 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within NADP metabolic process IMP
IMP: Inferred from mutant phenotype
9873043 MGI
involved in calcium ion import IMP
IMP: Inferred from mutant phenotype
18477811 MGI
acts upstream of or within carbohydrate phosphorylation IDA
IDA: Inferred from direct assay
141272 MGI
acts upstream of or within carbohydrate phosphorylation IMP
IMP: Inferred from mutant phenotype
7556622 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
7556622 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
18477811 MGI
acts upstream of or within glucose metabolic process IDA
IDA: Inferred from direct assay
141272 MGI
acts upstream of or within glucose metabolic process IMP
IMP: Inferred from mutant phenotype
7556622 MGI
acts upstream of or within intracellular glucose homeostasis IMP
IMP: Inferred from mutant phenotype
7553875 MGI
involved in intracellular glucose homeostasis IMP
IMP: Inferred from mutant phenotype
8530440 MGI
acts upstream of or within positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
7556622 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
18477811 MGI
acts upstream of or within regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
8530440 MGI
acts upstream of or within regulation of potassium ion transport IMP
IMP: Inferred from mutant phenotype
9662046 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
24187134 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
12931191 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10713097 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gck Protein Structure

COG5026

COG5026: cl34871 (15 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 465 a.a.
Protein Preferred Names Protein Names

hexokinase-4

  • HK IV

  • hexokinase type IV

  • hexokinase-D

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147141 HS-276 Inhibitor 98.93% Unkown
HY-15489 Scriptaid 98.59% Unkown
HY-10943 GNF-7 Inhibitor 99.70% Unkown
HY-123714 TL4-12 99.82% Unkown
HY-137342 SB1-G-187 Degrader 98.70% Unkown
HY-137343 DB-0646 Degrader 98.0% Unkown
HY-RS04706 FAM20C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-147141A HS-276 hydrochloride Inhibitor / Unkown
HY-147141B HS-276 formic Inhibitor / Unkown
HY-170365 HPK1-IN-55 Inhibitor / Unkown
HY-183809 ZSW Inhibitor / Unkown
HY-RS05329 GCK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05330 Gck Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05331 Gck Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08074 MAP4K2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08075 Map4k2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gck NCBI NCBI:2645