Cbll1 - Casitas B-lineage lymphoma-like 1 Gene

Also Known as Hakai; c-Cbl-like

Species: Mus musculus

Gene Type: protein coding
Gene ID: 104836

Summary

Enables identical protein binding activity and ubiquitin protein Ligase activity. Acts upstream of or within negative regulation of cell adhesion; positive regulation of cell migration; and positive regulation of endocytosis. Located in cytoplasm and nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in heart ventricle. Orthologous to human CBLL1 (Cbl proto-oncogene like 1). [provided by Alliance of Genome Resources, Apr 2022]

Cbll1 Products (3)

mRNA Protein Name
NM_001253847.1 NP_001240776.1 E3 ubiquitin-protein ligase Hakai isoform 1
NM_001253848.1 NP_001240777.1 E3 ubiquitin-protein ligase Hakai isoform 3
NM_134048.2 NP_598809.1 E3 ubiquitin-protein ligase Hakai isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22252131 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11836526 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
11836526 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of cell adhesion IDA
IDA: Inferred from direct assay
11836526 MGI
acts upstream of or within positive regulation of cell migration IDA
IDA: Inferred from direct assay
11836526 MGI
acts upstream of or within positive regulation of endocytosis IDA
IDA: Inferred from direct assay
11836526 MGI
Cellular Component GO Annotation Evidence References Source
part of RNA N6-methyladenosine methyltransferase complex IDA
IDA: Inferred from direct assay
29547716 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
29547716 MGI
located in nucleus IDA
IDA: Inferred from direct assay
29547716 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase Hakai

  • E-cadherin binding protein E7

  • RING-type E3 ubiquitin transferase Hakai

  • c-Cbl-like protein 1

  • casitas B-lineage lymphoma-transforming sequence-like protein 1

Cbll1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Cbll1 Q9JIY2 DOK1 Homo sapiens Q99704
Competition Binding
22252131
Cross
Cbll1 Q9JIY2 DOK1 Homo sapiens Q99704
Anti Tag CoIP
22252131
Cross
Cbll1 Q9JIY2 CTTN Homo sapiens Q14247
Anti Tag CoIP
22252131
Intra
Cbll1 Q9JIY2 Cttn Mus musculus Q60598
Anti Tag CoIP
22252131
Cross
Cbll1 Q9JIY2 CDH1 Homo sapiens P12830
Pull Down
22252131
Cross
Cbll1 Q9JIY2 CDH1 Homo sapiens P12830
NMR
22252131
Intra
Cbll1 Q9JIY2 CDH1 Homo sapiens P12830
Anti Tag CoIP
22252131
Cross
Cbll1 Q9JIY2 CDH1 Homo sapiens P12830
ITC
22252131
Intra
Cbll1 Q9JIY2 Cbll1 Mus musculus Q9JIY2
X-Ray Diffraction
22252131
Intra
Cbll1 Q9JIY2 Cbll1 Mus musculus Q9JIY2
GMS
22252131
Intra
Cbll1 Q9JIY2 Cbll1 Mus musculus Q9JIY2
DLS
22252131
Intra
Cbll1 Q9JIY2 Cbll1 Mus musculus Q9JIY2
Anti Tag CoIP
22252131
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02000 CBLL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20871 Cbll1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27388 Cbll1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbll1 NCBI NCBI:79872