Tdp1 - tyrosyl-DNA phosphodiesterase 1 Gene

Also Known as SCAN1; Gm40556; MLZ-501; 2810481F14Rik; 4921509N21Rik; E430034L06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 104884

Summary

Predicted to enable 3'-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding activity; and single-stranded DNA binding activity. Acts upstream of or within single strand break repair. Located in nucleus. Is expressed in ovary and testis. Used to study spinocerebellar ataxia type 1 with axonal neuropathy. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1 with axonal neuropathy. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2022]

Tdp1 Products (2)

mRNA Protein Name
NM_001379072.1 NP_001366001.1 tyrosyl-DNA phosphodiesterase 1 isoform 1
NM_028354.5 NP_082630.2 tyrosyl-DNA phosphodiesterase 1 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
21390131 MGI
acts upstream of or within single strand break repair IMP
IMP: Inferred from mutant phenotype
17914460 MGI
Cellular Component GO Annotation Evidence References Source
NOT located in cytoplasm IDA
IDA: Inferred from direct assay
17948061 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17948061 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosyl-DNA phosphodiesterase 1

  • protein expressed in male leptotene and zygotene spermatocytes 501

  • tyr-DNA phosphodiesterase 1

  • tyrosyl-DNA phodphodiesterase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110137 Furamidine dihydrochloride Inhibitor ≥99.0% Unkown
HY-119372 TDP1 Inhibitor-1 Inhibitor 98.33% Unkown
HY-W177546 CD00509 98.0% Unkown
HY-157886 TDP1 Inhibitor-3 Inhibitor 98.10% Unkown
HY-147750 TDP1 Inhibitor-2 Inhibitor 99.75% Unkown
HY-161853 TX-2552 Inhibitor 99.69% Unkown
HY-110137A Furamidine Inhibitor / Unkown
HY-175779 TDP1-IN-4 Inhibitor / Unkown
HY-176409 Phosphodiesterase-IN-4 Inhibitor / Unkown
HY-181080 TOP1/TDP1-IN-1 / Unkown
HY-183334 TDP1-IN-5 / Unkown
HY-183546 TDP1-IN-6 / Unkown
HY-RS14332 TDP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124486 NSC-88915 Inhibitor / Unkown
HY-RS17650 Tdp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24110 Tdp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tdp1 NCBI NCBI:55775