IGF2BP1 - insulin like growth factor 2 mRNA binding protein 1 Gene

Also Known as IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10642

About IGF2BP1

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,996,558-49,056,145 (from NCBI)

This gene has 6 transcripts (splice variants), 146 orthologues and 12 paralogues. Biased expression in testis (RPKM 3.6), placenta (RPKM 2.9) and 1 other tissue.

Summary

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

IGF2BP1 Products (2)

mRNA Protein Name
NM_001160423.2 NP_001153895.1 insulin-like growth factor 2 mRNA-binding protein 1 isoform 2
NM_006546.4 NP_006537.3 insulin-like growth factor 2 mRNA-binding protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: Inferred from direct assay
29476152 GOA
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
20080952 GOA
enables mRNA 5'-UTR binding IDA
IDA: Inferred from direct assay
9891060 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
17101699 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17289661 GOA
enables translation regulator activity IDA
IDA: Inferred from direct assay
9891060 GOA
Biological Process GO Annotation Evidence References Source
involved in CRD-mediated mRNA stabilization IDA
IDA: Inferred from direct assay
19029303 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
19029303 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
9891060 GOA
involved in positive regulation of cytoplasmic translation IDA
IDA: Inferred from direct assay
19029303 GOA
involved in regulation of mRNA stability involved in response to stress IMP
IMP: Inferred from mutant phenotype
17101699 GOA
Cellular Component GO Annotation Evidence References Source
part of CRD-mediated mRNA stability complex IDA
IDA: Inferred from direct assay
19029303 GOA
part of CRD-mediated mRNA stability complex IPI
IPI: Inferred from physical interaction
19029303 GOA
located in P-body IDA
IDA: Inferred from direct assay
29476152 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
9891060 GOA
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
17101699 GOA
located in cytosol IDA
IDA: Inferred from direct assay
19029303 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17289661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGF2BP1 Protein Structure

(4 - 69)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (85 - 150)

KH_1

KH_1: KH domain (198 - 260)

KH_1

KH_1: KH domain (280 - 343)

KH_1

KH_1: KH domain (409 - 469)

KH_1

KH_1: KH domain (490 - 553)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 577 a.a.
Protein Preferred Names Protein Names

insulin-like growth factor 2 mRNA-binding protein 1

  • IGF-II mRNA-binding protein 1

IGF2BP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IGF2BP1 Q9NZI8 DYRK1A Homo sapiens Q13627
Anti Bait CoIP
36950384
Intra
IGF2BP1 Q9NZI8 MOV10 Homo sapiens Q9HCE1
Anti Tag CoIP
35271311
Intra
IGF2BP1 Q9NZI8 STAU1 Homo sapiens O95793
Anti Tag CoIP
19029303
Intra
IGF2BP1 Q9NZI8 STAU1 Homo sapiens O95793
Anti Tag CoIP
35271311
Intra
IGF2BP1 Q9NZI8 STAU1 Homo sapiens O95793
Confocal
19029303
Cross: Cross-species interaction Intra: Intraspecies interaction

IGF2BP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83326 IGF2BP1 Antibody (YA3071) WB, IHC-P, IP Human, Mouse
HY-P83326A IGF2BP1 Antibody (YA3071)(PBS only) WB, IHC-P, IP Human, Mouse

Related Diseases

Diseases Alias
Thyroid Sarcoma

  • Sarcoma Of The Thyroid Gland

  • Thyroid Gland Sarcoma
Meningioma, Familial

  • Meningioma

  • Familial Meningioma

  • Meningioma, Familial, Susceptibility To

  • Meningeal Neoplasm

  • Meningeal Neoplasms

  • Meningiomas

  • Meningioma, Nf2-Related, Somatic

  • Meningioma, Sis-Related

  • Meningothelial Cell Tumor

  • Neoplasm Of The Meninges

  • Primary Meningeal Tumor

  • Familial Multiple Meningioma

  • MNGMA

  • Meningioma, Benign, No Icd-O Subtype

  • Intracranial Meningioma

  • Meningothelial Cell Neoplasm

  • Supratentorial Meningioma

  • Primary Neoplasm Of Spinal Meninges

  • Benign Intracranial Meningioma

  • Benign Meningioma

  • Meningeal Tumours

  • Meningeal Sarcoma Of Unspecified Site

  • Meningothelial Sarcoma Of Unspecified Site
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Microphthalmia

  • Microphthalmos

  • Isolated Anophthalmia-Microphthalmia Syndrome

  • Isolated Microphthalmia-Anophthalmia-Coloboma

  • Simple Microphthalmos

  • Clinical Anophthalmia

  • Isolated Anophthalmia - Microphthalmia

  • Isolated Pure Microphthalmia

  • Mac Spectrum

  • Microphthalmia-Anophthalmia-Coloboma Spectrum

  • Primitive Anophthalmia

  • Globe Of Eye Small

  • Small Eyeball

  • Hypoplasia Of Eye

  • Isolated Nanophthalmos

  • Rudimentary Eye

  • Dysplasia Of Eye
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-144873 AVJ16 Inducer 99.60% Unkown
HY-124447 BTYNB 98.0% Unkown
HY-156110 IGF2BP1-IN-1 99.94% Unkown
HY-RS06619 IGF2BP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16849 Igf2bp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23290 Igf2bp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris IGF2BP1 VGNC VGNC:41898
Macaca mulatta IGF2BP1 VGNC VGNC:73452
Felis catus IGF2BP1 VGNC VGNC:62888
Rattus norvegicus IGF2BP1 RGD RGD:708580
Bos taurus IGF2BP1 VGNC VGNC:30079
Mus musculus IGF2BP1 MGD MGI:1890357
Others IGF2BP1 NCBI