LILRB4 - leukocyte immunoglobulin like receptor B4 Gene

Also Known as B4; ILT3; LIR5; CD85K; ILT-3; LIR-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11006

About LILRB4

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,662,985-54,668,718 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 296 orthologues and 25 paralogues. Broad expression in appendix (RPKM 9.2), lymph node (RPKM 8.1) and 17 other tissues.

Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB4 Products (12)

mRNA Protein Name
NM_001278426.4 NP_001265355.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 1 precursor
NM_001278427.4 NP_001265356.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 2 precursor
NM_001278428.4 NP_001265357.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 3 precursor
NM_001278429.4 NP_001265358.3 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 4
NM_001278430.4 NP_001265359.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 5 precursor
NM_001394933.1 NP_001381862.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 6 precursor
NM_001394934.1 NP_001381863.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 7 precursor
NM_001394935.1 NP_001381864.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 8 precursor
NM_001394936.1 NP_001381865.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 9
NM_001394937.1 NP_001381866.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 10
NM_001394938.1 NP_001381867.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 11
NM_001394939.1 NP_001381868.1 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 12 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables apolipoprotein binding IDA
IDA: Inferred from direct assay
30333625 GOA
enables fibronectin binding IDA
IDA: Inferred from direct assay
34089617 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18802077 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
16493035 GOA
enables signaling receptor inhibitor activity IDA
IDA: Inferred from direct assay
9151699 GOA
enables transmembrane receptor protein tyrosine kinase inhibitor activity IDA
IDA: Inferred from direct assay
9151699 GOA
enables transmembrane receptor protein tyrosine kinase inhibitor activity IMP
IMP: Inferred from mutant phenotype
16493035 GOA
Biological Process GO Annotation Evidence References Source
involved in Fc receptor mediated inhibitory signaling pathway IDA
IDA: Inferred from direct assay
16493035 GOA
involved in interleukin-10-mediated signaling pathway IEP
IEP: Inferred from expression pattern
17163451 GOA
involved in negative regulation of IP-10 production IMP
IMP: Inferred from mutant phenotype
19380766 GOA
involved in negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
19380766 GOA
involved in negative regulation of T cell costimulation IMP
IMP: Inferred from mutant phenotype
17163451 GOA
involved in negative regulation of T cell cytokine production IDA
IDA: Inferred from direct assay
18420485 GOA
involved in negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
17163451 GOA
involved in negative regulation of T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
22387553 GOA
involved in negative regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16493035 GOA
involved in negative regulation of activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
19380766 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
19380766 GOA
involved in negative regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
19380766 GOA
involved in negative regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
19380766 GOA
involved in negative regulation of cytotoxic T cell differentiation IMP
IMP: Inferred from mutant phenotype
16493035 GOA
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
19380766 GOA
involved in negative regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
18420485 GOA
involved in negative regulation of interleukin-2 production IDA
IDA: Inferred from direct assay
18420485 GOA
involved in negative regulation of interleukin-5 production IDA
IDA: Inferred from direct assay
18420485 GOA
involved in negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
19380766 GOA
involved in negative regulation of miRNA transcription IDA
IDA: Inferred from direct assay
22387553 GOA
involved in negative regulation of monocyte activation IDA
IDA: Inferred from direct assay
19833736 GOA
involved in negative regulation of monocyte activation IMP
IMP: Inferred from mutant phenotype
9151699 GOA
involved in negative regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
18802077 GOA
involved in negative regulation of protein localization to nucleus IDA
IDA: Inferred from direct assay
22387553 GOA
involved in negative regulation of protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
9151699 GOA
involved in negative regulation of protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
16493035 GOA
involved in negative regulation of signaling receptor activity IDA
IDA: Inferred from direct assay
9151699 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
19833736 GOA
involved in negative regulation of type II interferon production IDA
IDA: Inferred from direct assay
20007427 GOA
involved in positive regulation of CD8-positive, alpha-beta T cell differentiation IDA
IDA: Inferred from direct assay
18420485 GOA
involved in positive regulation of T cell anergy IMP
IMP: Inferred from mutant phenotype
16493035 GOA
involved in positive regulation of regulatory T cell differentiation IDA
IDA: Inferred from direct assay
20935202 GOA
involved in receptor internalization IMP
IMP: Inferred from mutant phenotype
9151699 GOA
involved in tolerance induction IDA
IDA: Inferred from direct assay
18420485 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
9151699 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LILRB4 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (28 - 115)

Ig_3

Ig_3: Immunoglobulin domain (123 - 198)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 449 a.a.
Protein Preferred Names Protein Names

leukocyte immunoglobulin-like receptor subfamily B member 4

  • CD85 antigen-like family member K

LILRB4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LILRB4 Q8NHJ6 PTPN6 Homo sapiens P29350
Anti Bait CoIP
18802077
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LILRB4 Proteins

Cat. No. Product Name Accession Purity
HY-P72519 LILRB4/CD85k/ILT3 Protein, Human (HEK293, His) Q8NHJ6-1 (Q22-E259) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76440 LILRB4/CD85k/ILT3 Protein, Human (Biotinylated, HEK293, His) Q8NHJ6-1 (Q22-E259) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76441 LILRB4/CD85k/ILT3 Protein, Human (HEK293, hFc) Q8NHJ6-1/NP_001265356.2 (M21-H257) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77743 LILRB4/CD85k/ILT3 Protein, Human (HEK293, His-Avi) Q8NHJ6-1 (Q22-H257) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77744 LILRB4/CD85k/ILT3 Protein, Human (Biotinylated, HEK293, His-Avi) Q8NHJ6-1 (Q22-H257) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78645 FITC-Labeled LILRB4/CD85k/ILT3 Protein, Human (HEK293, His) Q8NHJ6-1 (Q22-H257) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78646 FITC-Labeled LILRB4/CD85k/ILT3 Protein, Human (HEK293, Fc) Q8NHJ6-1 (Q22-R256) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700779 LILRB4/CD85k/ILT3 Domain 1 Protein, Human (Biotinylated, HEK293, His-Avi) AAH26309.1 (Q22-T118) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700780 LILRB4/CD85k/ILT3 Domain 1 Protein, Human (HEK293, His-Avi) AAH26309.1 (Q22-T118) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P701018 LILRB4/CD85k/ILT3 Domain 2 Protein, Human (Biotinylated, HEK293, His-Avi) AAH26309.1 (G119-E259) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P701064 LILRB4/CD85k/ILT3 Domain 1+hinge Protein, Human (Biotinylated, HEK293, His-Avi) AAH26309.1 (Q22-K123) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P701065 LILRB4/CD85k/ILT3 Domain 1+hinge Protein, Human (HEK293, His-Avi) AAH26309.1 (Q22-K123) ≥ 95%, as determined by reducing SDS-PAGE.

LILRB4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84679 CD85K Antibody (YA4376) IHC-P, ICC/IF, FC, ELISA Human
HY-P84679A CD85K Antibody (YA4376)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991307 BND-35 Inhibitor / Phase 1

Pre-clinical Phase

Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990092 Rolistobart Inhibitor 97.41% Unkown
HY-P991308 TRX385 Inhibitor / Unkown
HY-P992389 IO-202 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LILRB4 RGD RGD:1359090
Others LILRB4 NCBI