Adam12 - a disintegrin and metallopeptidase domain 12 (meltrin alpha) Gene

Also Known as Mltna

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11489

Summary

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein that localizes to the cell surface. About a third of the mice lacking the encoded protein die before weaning. Overexpression of the encoded protein in a mouse model of Duchenne muscular dystrophy alleviates the muscle pathology by preventing cell necrosis and inflammation. [provided by RefSeq, May 2016]

Adam12 Products (1)

mRNA Protein Name
NM_007400.2 NP_031426.2 disintegrin and metalloproteinase domain-containing protein 12 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10788519 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 12

  • a disintegrin and metalloprotease domain 12

  • a disintegrin and metalloproteinase domain 12 (meltrin alpha)

Adam12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Adam12 Q61824 ACTN2 Homo sapiens P35609
Pull Down
10788519
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Adam12 Proteins

Cat. No. Product Name Accession Purity
HY-P72061 ADAM12 Protein, Mouse (sf9, His-Myc) Q61824 (E206-G706) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00269 ADAM12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18084 Adam12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24558 Adam12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adam12 NCBI NCBI:8038