Adh5 - alcohol dehydrogenase 5 (class III), chi polypeptide Gene

Also Known as Adh3; Adh-5; GSNOR

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11532

About Adh5

Chromosome 3: 138,148,854-138,161,260 forward strand.GRCm39:CM000996.3

This gene has 7 transcripts (splice variants), 404 orthologues, 16 paralogues and is associated with 9 phenotypes. Ubiquitous expression in liver E18 (RPKM 86.3), CNS E11.5 (RPKM 59.7) and 25 other tissues.

Summary

Enables S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase (NAD+) activity; and identical protein binding activity. Acts upstream of or within several processes, including formaldehyde catabolic process; peptidyl-cysteine S-nitrosylation; and response to lipopolysaccharide. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in AMED syndrome and asthma. Orthologous to human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide). [provided by Alliance of Genome Resources, Apr 2022]

Adh5 Products (2)

mRNA Protein Name
NM_001288578.1 NP_001275507.1 alcohol dehydrogenase class-3 isoform 2
NM_007410.3 NP_031436.2 alcohol dehydrogenase class-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity IMP
IMP: Inferred from mutant phenotype
15919956 MGI
enables alcohol dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
3996732 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
3996732 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within formaldehyde catabolic process IMP
IMP: Inferred from mutant phenotype
10358022 MGI
acts upstream of or within peptidyl-cysteine S-nitrosylation IMP
IMP: Inferred from mutant phenotype
14980227 MGI
acts upstream of or within positive regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
14980227 MGI
acts upstream of or within respiratory system process IMP
IMP: Inferred from mutant phenotype
15919956 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
14980227 MGI
acts upstream of or within response to nitrosative stress IMP
IMP: Inferred from mutant phenotype
14980227 MGI
acts upstream of or within retinoid metabolic process IMP
IMP: Inferred from mutant phenotype
12027900 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
3996732 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adh5 Protein Structure

alcohol_DH_class_III

alcohol_DH_class_III: cd08300 (5 - 372)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
Protein Preferred Names Protein Names

alcohol dehydrogenase class-3

  • ADH-B2

  • FALDH

  • FDH

  • GSH-FDH

  • S-(hydroxymethyl)glutathione dehydrogenase

  • S-nitrosoglutathione reductase

  • alcohol dehydrogenase 2

  • alcohol dehydrogenase B2

  • alcohol dehydrogenase class-III

  • glutathione-dependent formaldehyde dehydrogenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00370 ADH5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00371 Adh5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00372 Adh5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00373 ADH6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adh5 NCBI NCBI:128