2. Gene
  3. Adh5 - alcohol dehydrogenase 5 (class III), chi polypeptide Gene

Adh5 - alcohol dehydrogenase 5 (class III), chi polypeptide Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Adh3; Adh-5; GSNOR

Gene ID: 11532 | Gene type: protein coding

About Adh5

Chromosome 3: 138,148,854-138,161,260 forward strand.GRCm39:CM000996.3

This gene has 7 transcripts (splice variants), 404 orthologues, 16 paralogues and is associated with 9 phenotypes. Ubiquitous expression in liver E18 (RPKM 86.3), CNS E11.5 (RPKM 59.7) and 25 other tissues.

Summary

Enables S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase (NAD+) activity; and identical protein binding activity. Acts upstream of or within several processes, including formaldehyde catabolic process; peptidyl-cysteine S-nitrosylation; and response to lipopolysaccharide. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in AMED syndrome and asthma. Orthologous to human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide). [provided by Alliance of Genome Resources, Apr 2022]

Adh5 Products(2)

mRNA Protein Name
NM_001288578.1 NP_001275507.1 alcohol dehydrogenase class-3 isoform 2
NM_007410.3 NP_031436.2 alcohol dehydrogenase class-3 isoform 1

Adh5 Protein Structure

alcohol_DH_class_III

alcohol_DH_class_III: cd08300 (5 - 372)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
Protein Preferred Names Protein Names

alcohol dehydrogenase class-3

ADH-B2

FALDH

FDH

GSH-FDH

S-(hydroxymethyl)glutathione dehydrogenase

S-nitrosoglutathione reductase

alcohol dehydrogenase 2

alcohol dehydrogenase B2

alcohol dehydrogenase class-III

glutathione-dependent formaldehyde dehydrogenase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00370 ADH5 Human Pre-designed siRNA Set A / Unkown
HY-RS00371 Adh5 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00372 Adh5 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adh5 NCBI NCBI:128