Lrpap1 - LDL receptor related protein associated protein 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116565

Summary

Enables Lipase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; negative regulation of amyloid-beta clearance; and negative regulation of very-low-density lipoprotein particle clearance. Located in rough endoplasmic reticulum lumen and vesicle. Used to study membranous glomerulonephritis. Biomarker of membranous glomerulonephritis. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Lrpap1 Products (1)

mRNA Protein Name
NM_001169113.1 NP_001162584.1 alpha-2-macroglobulin receptor-associated protein precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lipase binding IPI
IPI: Inferred from physical interaction
16517593 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10571241 RGD
Cellular Component GO Annotation Evidence References Source
located in rough endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
8223699 RGD
located in vesicle IDA
IDA: Inferred from direct assay
8223699 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-2-macroglobulin receptor-associated protein

  • RAP

  • alpha-2-MRAP

  • gp330-binding 45 kDa protein

  • low density lipoprotein receptor-related protein-associated protein 1

Lrpap1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Lrpap1 Q99068 Lrp8 Mus musculus Q924X6
Pull Down
10571241
Cross
Lrpap1 Q99068 VLDLR Homo sapiens P98155
Pull Down
10571241
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0009A Cetrorelix Acetate Antagonist 99.98% Unkown
HY-P0009B Cetrorelix diacetate Antagonist / Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07803 LRPAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18095 Lrpap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24570 Lrpap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrpap1 NCBI NCBI:4043