Csf2 - colony stimulating factor 2 Gene

Also Known as Gmcsf; Gm-csf

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116630

Summary

Enables cytokine activity. Involved in several processes, including cellular response to lipopolysaccharide; macrophage activation; and response to silicon dioxide. Located in extracellular space. Used to study Parkinsonism and myocardial infarction. Biomarker of abdominal aortic aneurysm; interstitial cystitis; and lung disease (multiple). Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Csf2 Products (1)

mRNA Protein Name
NM_053852.1 NP_446304.1 granulocyte-macrophage colony-stimulating factor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
8535150 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18387647 RGD
involved in dendritic cell differentiation IDA
IDA: Inferred from direct assay
8535150 RGD
involved in epithelial fluid transport IDA
IDA: Inferred from direct assay
14504066 RGD
involved in histamine secretion IDA
IDA: Inferred from direct assay
9685678 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
8304053 RGD
involved in regulation of circadian sleep/wake cycle, sleep IMP
IMP: Inferred from mutant phenotype
12047622 RGD
involved in response to fluid shear stress IEP
IEP: Inferred from expression pattern
15010288 RGD
involved in response to silicon dioxide IEP
IEP: Inferred from expression pattern
21505002 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
16673407 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
21442011 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

granulocyte-macrophage colony-stimulating factor

  • CSF

  • colony stimulating factor 2 (granulocyte-macrophage)

  • colony-stimulating factor

Recombinant Csf2 Proteins

Cat. No. Product Name Accession Purity
HY-P7094 GM-CSF Protein, Rat (CHO) P48750 (A18-K144) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72629 GM-CSF Protein, Rat (HEK293, His) P48750 (A18-K144) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99207 Lenzilumab 99.64% Phase 3
HY-P99307 Namilumab Inhibitor 99.47% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N7038A Phytohemagglutinin P Activator / Unkown
HY-RS03231 CSF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03232 CSF2RA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03233 CSF2RB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174733 Human CSF2RA mRNA / Unkown
HY-RS16786 Csf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18089 Csf2ra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18705 Csf2rb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23226 Csf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24563 Csf2ra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25192 Csf2rb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990094 Trabikibart 99.17% Unkown
HY-P990975 Birinkibart 98.26% Unkown
HY-P990381 Anti-CSF2/GM-CSF Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Csf2 NCBI NCBI:1437