Cdk5r1 - cyclin-dependent kinase 5 regulatory subunit 1 Gene

Also Known as p35; Cdk5r

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116671

Summary

Enables several functions, including Cadherin binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and Ephrin Receptor binding activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; nervous system development; and regulation of synaptic vesicle cycle. Located in several cellular components, including dendritic spine; growth cone; and postsynaptic density. Part of protein kinase 5 complex. Is active in presynapse. Biomarker of hypothyroidism and trigeminal neuralgia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5r1 Products (1)

mRNA Protein Name
NM_053891.2 NP_446343.1 cyclin-dependent kinase 5 activator 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cadherin binding IDA
IDA: Inferred from direct assay
10753743 RGD
enables calcium ion binding IDA
IDA: Inferred from direct assay
12223541 RGD
enables cyclin-dependent protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
8662984 RGD
enables cyclin-dependent protein serine/threonine kinase activator activity IGI
IGI: Inferred from genetic interaction
17517623 RGD
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
17143272 RGD
enables kinase activity IDA
IDA: Inferred from direct assay
8846918 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8846918 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
25665755 RGD
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
8662984 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled acetylcholine receptor signaling pathway IDA
IDA: Inferred from direct assay
11276227 RGD
involved in embryo development ending in birth or egg hatching IDA
IDA: Inferred from direct assay
11276227 RGD
involved in ionotropic glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
12223541 RGD
involved in neuron differentiation IDA
IDA: Inferred from direct assay
8846918 RGD
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
8846918 RGD
involved in positive regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
16192386 RGD
involved in regulation of synaptic vesicle cycle IDA
IDA: Inferred from direct assay
24254883 RGD
involved in regulation of synaptic vesicle cycle IEP
IEP: Inferred from expression pattern
24254883 RGD
involved in regulation of synaptic vesicle cycle IMP
IMP: Inferred from mutant phenotype
24254883 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
8846918 RGD
located in contractile muscle fiber IDA
IDA: Inferred from direct assay
11276227 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
11276227 RGD
located in dendrite IDA
IDA: Inferred from direct assay
8846918 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
12223541 RGD
located in growth cone IDA
IDA: Inferred from direct assay
8846918 RGD
located in membrane IDA
IDA: Inferred from direct assay
11276227 RGD
located in neuromuscular junction IDA
IDA: Inferred from direct assay
11276227 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8846918 RGD
located in nucleus IDA
IDA: Inferred from direct assay
16192386 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
17143272 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
24254883 RGD
part of protein kinase 5 complex IDA
IDA: Inferred from direct assay
8662984 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase 5 activator 1

  • CDK5 activator 1

  • TPKII regulatory subunit

  • p23

  • tau protein kinase II 23 kDa subunit

Cdk5r1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cdk5r1 P61810 Cdk5 Rattus norvegicus Q03114
Anti Bait CoIP
17036052
Intra
Cdk5r1 P61810 Cdk5 Rattus norvegicus Q03114
Anti Bait CoIP
17341134
Intra
Cdk5r1 P61810 Fzr1 Rattus norvegicus B1WCA1
Protein Kinase Assay
18818692
Intra
Cdk5r1 P61810 Fzr1 Rattus norvegicus B1WCA1
Anti Bait CoIP
18818692
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02387 CDK5R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20536 Cdk5r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27045 Cdk5r1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk5r1 NCBI NCBI:8851