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Cdk5 - cyclin-dependent kinase 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 140908

About Cdk5

Primary_assembly 4: 10,754,687-10,760,112 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 170 orthologues, 24 paralogues and is associated with 16 phenotypes. Biased expression in Brain (RPKM 242.9), Adrenal (RPKM 12.7) and 9 other tissues.

Summary

Enables several functions, including Ephrin Receptor binding activity; protein kinase activity; and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in several processes, including cellular response to amyloid-beta; positive regulation of apoptotic process; and protein phosphorylation. Acts upstream of or within protein phosphorylation. Located in several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Part of protein kinase 5 complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and neuromuscular junction. Colocalizes with microtubule. Used to study brain ischemia; mental depression; and trigeminal neuralgia. Biomarker of Alzheimer's disease; transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5 Products (1)

mRNA	Protein	Name
NM_080885.2	NP_543161.1	cyclin-dependent kinase 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11675505	RGD
enables cytoskeletal protein binding	IPI IPI: Inferred from physical interaction	9313898	RGD
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	17143272	RGD
enables histone kinase activity	IDA IDA: Inferred from direct assay	16407116	RGD
enables kinase activity	IDA IDA: Inferred from direct assay	8846918	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8846918	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	12084709	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19700222	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8662984	RGD
enables tau-protein kinase activity	IDA IDA: Inferred from direct assay	15994305	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	19151707	RGD
involved in cellular response to amyloid-beta	IDA IDA: Inferred from direct assay	26224839	RGD
involved in cortical actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15331630	RGD
involved in exocytosis	IMP IMP: Inferred from mutant phenotype	15331630	RGD
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	28153522	RGD
involved in neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15592431	RGD
involved in neuron differentiation	IDA IDA: Inferred from direct assay	8846918	RGD
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	8846918	RGD
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	12535933	RGD
involved in nucleocytoplasmic transport	IMP IMP: Inferred from mutant phenotype	16887799	RGD
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	12691662	RGD
involved in positive regulation of glial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	28153522	RGD
involved in positive regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	16192386	RGD
involved in positive regulation of presynaptic cytosolic calcium concentration	IMP IMP: Inferred from mutant phenotype	23699505	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	28153522	RGD
involved in positive regulation of voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	23699505	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	15992363	RGD
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	17202132	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	8662984	RGD
involved in regulated exocytosis	IMP IMP: Inferred from mutant phenotype	15331630	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	23699505	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	23699505	RGD
involved in regulation of synapse pruning	EXP EXP: Inferred from Experiment	17143272	RGD
involved in regulation of synapse pruning	IDA IDA: Inferred from direct assay	17143272	RGD
involved in regulation of synapse pruning	IMP IMP: Inferred from mutant phenotype	17143272	RGD
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11675505	RGD
involved in skeletal muscle tissue development	IEP IEP: Inferred from expression pattern	15208659	RGD
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	12855954	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	17143272	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	17143272	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	17143272	RGD
located in axon	IDA IDA: Inferred from direct assay	8846918	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	10683146	RGD
located in dendrite	IDA IDA: Inferred from direct assay	8846918	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	17143272	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17143272	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17143272	RGD
located in growth cone	IDA IDA: Inferred from direct assay	8846918	RGD
located in membrane	IDA IDA: Inferred from direct assay	10683146	RGD
located in microtubule	IDA IDA: Inferred from direct assay	17491008	RGD
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	11276227	RGD
located in neuromuscular junction	IDA IDA: Inferred from direct assay	11276227	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	10683146	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8846918	RGD
located in nucleus	IDA IDA: Inferred from direct assay	16192386	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	11276227	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	17143272	RGD
located in presynapse	IMP IMP: Inferred from mutant phenotype	23699505	RGD
part of protein kinase 5 complex	IDA IDA: Inferred from direct assay	8662984	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk5 Protein Structure

STKc_CDK5

0
100
200
292 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 5	TPKII catalytic subunit cell division protein kinase 5 cyclin-dependent-like kinase 5 serine/threonine-protein kinase PSSALRE tau protein kinase II catalytic subunit

Cdk5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Cdk5	Q03114	Cdk5r1	Rattus norvegicus	P61810	Anti Bait CoIP	17341134
Cross	Cdk5	Q03114	NTRK2	Homo sapiens	Q16620	Protein Kinase Assay	17341134
Cross	Cdk5	Q03114	NTRK2	Homo sapiens	Q16620	Anti Tag CoIP	17341134
Intra	Cdk5	Q03114	Ntrk2	Rattus norvegicus	Q63604	Protein Kinase Assay	17341134
Intra	Cdk5	Q03114	Ntrk2	Rattus norvegicus	Q63604	Anti Bait CoIP	17341134
Intra	Cdk5	Q03114	Ntrk3	Rattus norvegicus	Q03351	Protein Kinase Assay	17341134
Intra	Cdk5	Q03114	Ntrk3	Rattus norvegicus	Q03351	Anti Bait CoIP	17341134

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-10492	Dinaciclib	Inhibitor	99.80%	Yes
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes

Clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.51%	Phase 3
HY-30237	(R)-Roscovitine	Inhibitor	99.53%	Phase 2
HY-X0009	Tambiciclib	Inhibitor	99.68%	Phase 2
HY-50940	AT7519	Inhibitor	99.69%	Phase 2
HY-137478	KB-0742	Inhibitor	99.63%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.90%	Phase 2
HY-10012	AZD-5438	Inhibitor	99.91%	Phase 1
HY-10014	R547	Inhibitor	99.57%	Phase 1
HY-12871B	Atuveciclib	Inhibitor	99.75%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.67%	Phase 1

Pre-clinical Phase

Bioactive Molecules (82)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12302	Kenpaullone	Inhibitor	98.20%	Unkown
HY-10580	GSK 3 Inhibitor IX	Inhibitor	99.73%	Unkown
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Unkown
HY-15154	NG 52	Inhibitor	99.88%	Unkown
HY-18340	(R)-CR8	Inhibitor	99.52%	Unkown
HY-18299A	Purvalanol A	Inhibitor	98.61%	Unkown
HY-137478A	KB-0742 dihydrochloride	Inhibitor	98.77%	Unkown
HY-108359	Alsterpaullone	Inhibitor	99.85%	Unkown
HY-144117	GFB-12811	Inhibitor	98.04%	Unkown
HY-11009	CGP60474	Inhibitor	98.90%	Unkown
HY-13461A	PHA-767491 hydrochloride	Inhibitor	99.49%	Unkown
HY-X0150	JSH-150	Inhibitor	98.36%	Unkown
HY-103221	MeBIO	Inhibitor	98.0%	Unkown
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	99.37%	Unkown
HY-13461	PHA-767491	Inhibitor	99.97%	Unkown
HY-103712	Samuraciclib	Inhibitor	99.55%	Unkown
HY-123772	CDK5 inhibitor 20-223	Inhibitor	99.62%	Unkown
HY-18299	Purvalanol B	Inhibitor	97.0%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-112358	GW8510	Inhibitor	99.04%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.93%	Unkown
HY-119940	MC180295	Inhibitor	98.07%	Unkown
HY-112272	Lerociclib	Inhibitor	96.42%	Unkown
HY-145694	CDK5-IN-3	Inhibitor	99.49%	Unkown
HY-151071	TMX-3013	Inhibitor	98.02%	Unkown
HY-W011428	Olomoucine	Inhibitor	99.88%	Unkown
HY-112403	(S)-Roscovitine	Inhibitor	99.15%	Unkown
HY-50943	AT7519 Hydrochloride	Inhibitor	99.16%	Unkown
HY-15504A	RGB-286638 free base	Inhibitor	98.09%	Unkown
HY-155218	TMX-2172	Degrader	99.38%	Unkown
HY-117025A	Manzamine A hydrochloride	Inhibitor	99.66%	Unkown
HY-151069	TMX-2039	Inhibitor	99.42%	Unkown
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Unkown
HY-121035	7BIO	Inhibitor	99.20%	Unkown
HY-107419	NU6140	Inhibitor	99.53%	Unkown
HY-14372	BS-194	Inhibitor	99.13%	Unkown
HY-P10440	Cdk5i peptide	Inhibitor	98.93%	Unkown
HY-137342	SB1-G-187	Degrader	98.70%	Unkown
HY-154851	GSK-3 inhibitor 3	Inhibitor	99.10%	Unkown
HY-139725	CDK5-IN-1	Inhibitor	98.47%	Unkown
HY-123045	PNU-292137	Inhibitor	99.95%	Unkown
HY-136726	CGP-82996	Inhibitor	98.12%	Unkown
HY-119715	AG-012986	Inhibitor	99.78%	Unkown
HY-111930	5-Iodo-indirubin-3'-monoxime	Inhibitor	98.12%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.88%	Unkown
HY-50940A	AT7519 TFA	Inhibitor	99.75%	Unkown
HY-X0009A	Tambiciclib dimaleate	Inhibitor	99.53%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-114903	(E/Z)-BIO-acetoxime	Inhibitor	99.9%	Unkown
HY-154852	GSK-3 inhibitor 4	Inhibitor	99.02%	Unkown
HY-103381	NSC693868	Inhibitor	99.0%	Unkown
HY-103383	(R)-DRF053 dihydrochloride	Inhibitor	99.30%	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-117025	Manzamine A	Inhibitor	98.2%	Unkown
HY-164906	TMX-2138	Degrader	98.99%	Unkown
HY-112468	PNU112455A hydrochloride	Inhibitor	99.56%	Unkown
HY-N12625	(R)-(+)-O-Demethylbuchenavianine	Inhibitor	98.67%	Unkown
HY-151409	CDK1-IN-5	Inhibitor	/	Unkown
HY-151407	CDK1-IN-3	Inhibitor	/	Unkown
HY-110368	BS-181 dihydrochloride	Inhibitor	/	Unkown
HY-184911	CDK6 ligand-3	Degrader	/	Unkown
HY-145693	CDK5-IN-2	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-178142	Multi-kinase-IN-7	Inhibitor	/	Unkown
HY-112336	Aloisine RP106	Inhibitor	/	Unkown
HY-182028	17β-HSD10-IN-4		/	Unkown
HY-137478B	KB-0742 hydrochloride	Inhibitor	/	Unkown
HY-173347	BLINK11	Inhibitor	/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-112363	Aloisine A	Inhibitor	/	Unkown
HY-111931	Indirubin-3'-monoxime-5-sulphonic acid	Inhibitor	/	Unkown
HY-151408	CDK1-IN-4	Inhibitor	/	Unkown
HY-184913	JHK-02-102-1	Degrader	/	Unkown
HY-173348	BLINK15	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-111932	Indirubin-5-sulfonate	Inhibitor	/	Unkown
HY-161595	CDK5-IN-4	Inhibitor	/	Unkown
HY-150641	CDK-IN-9	Inhibitor	/	Unkown
HY-182470	AG-012986 dihydrochloride	Inhibitor	/	Unkown
HY-183280	17β-HSD10/CDK5-IN-1	Inhibitor	/	Unkown
HY-182986	LS-Q2	Inhibitor	/	Unkown
HY-183235	NS-0011	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdk5	NCBI	NCBI:1020