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Cat. No.: HY-134623

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GSK3β/CDK5/CK1 IN-1

GSK3β/CDK5/CK1 IN-1 is a kinase inhibitor targeting GSK-3, CDK5, and CK1. GSK3β/CDK5/CK1 IN-1 is used in the research of cognitive, neurodegenerative, or neurological diseases or disorders.

For research use only. We do not sell to patients.

CAS No.: 1464788-75-7
Formula: C₁₂H₁₀N₄O
Molecular Weight:226.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GSK3β/CDK5/CK1 IN-1 Chemical Structure

CAS No.: 1464788-75-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

CDK5

CK1

GSK3β

All GSK-3 Isoforms :

All CDK Isoforms :

In Vitro

GSK3β/CDK5/CK1 IN-1 (Compound 1) exhibits potent inhibitory activity against human recombinant Cdk5/p35 kinase in an ADP-Glo luminescence-based Cdk5/p35 kinase assay using histone H1 as substrate with incubation at room temperature for 40 min, with pEC₅₀ = 8.2^[1].
GSK3β/CDK5/CK1 IN-1 (40 min) exhibits inhibitory activity against human recombinant GSK-3β kinase with a pEC₅₀ of 6.9, and its inhibitory potency against GSK-3β is weaker than that against Cdk5^[1].
GSK3β/CDK5/CK1 IN-1 exhibits inhibitory activity against human recombinant CK1ε kinase in an ADP-Glo luminescence-based CK1ε kinase assay using CK1 peptide substrate as the substrate after incubation at room temperature for 40 min, with pEC₅₀ = 6.1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1464788-75-7
Molecular Weight 226.23
Formula C₁₂H₁₀N₄O
SMILES

OC1=C(C2=CC=NC(N)=N2)C3=C(C=CC=C3)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Noscira SA. WO 2013/149976 A1. International application published under the Patent Cooperation Treaty; 2013 Oct 10.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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