1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK1-IN-3

CDK1-IN-3 

Cat. No.: HY-151407
Handling Instructions

CDK1-IN-3 (8g) is a selective CDK1 inhibitor with IC50s of 36.8, 305.17 and 369.37 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-3 inhibits the growth of cancer cells by affecting cell cycle. CDK1-IN-3 can be used for the research of cancer.

For research use only. We do not sell to patients.

CDK1-IN-3 Chemical Structure

CDK1-IN-3 Chemical Structure

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Description

CDK1-IN-3 (8g) is a selective CDK1 inhibitor with IC50s of 36.8, 305.17 and 369.37 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-3 inhibits the growth of cancer cells by affecting cell cycle. CDK1-IN-3 can be used for the research of cancer[1].

IC50 & Target

CDK1

36.8 nM (IC50)

CDK2

305.17 nM (IC50)

CDK5

369.37 nM (IC50)

In Vitro

CDK1-IN-3 (0-10 μM; 24 h) inhibits the growth of PDAC, melanoma, leukemia, colon and breast cancer cells[1].
CDK1-IN-3 (0-1 μM) inhibits CDK1, CDK2 and CDK5 with IC50s of 36.8, 305.17 and 369.37 nM, respectively[1].
CDK1-IN-3 (0-10 μM) inhibits AXL, PTK2B, FGFR, JAK1, IGF1R and BRAF kinases with IC50s of 5655, 3632, 4626, 5265, 5514 and 2829 nM, respectively[1].
CDK1-IN-3 (0.51 μM; 24 h) decreases CDK1 protein level in virto and affects cell cycle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: PDAC, melanoma, leukemia, colon and breast cancer cell lines
Concentration: 0-10 μM
Incubation Time: 24 hours
Result: Inhibited cell growth of PDAC, melanoma, leukemia, colon, and breast cancer cells over 61%, and inhibited MDA-PATC53 and PL45 cells with IC50s of 0.51 and 0.74 μM, respectively.

Western Blot Analysis[1]

Cell Line: MDA-PATC53 cell line
Concentration: 0.51 μM
Incubation Time: 24 hours
Result: Downregulated CDK1 protein level compared to untreated cells.

Western Blot Analysis[1]

Cell Line: MDA-PATC53 cell line
Concentration: 0.51 μM
Incubation Time: 24 hours
Result: Significantly arrested in G2/M phase of the cell cycle compared with the untreated cells.
Molecular Weight

555.98

Formula

C28H25ClF3N5O2

SMILES

O=C(N1CCN(C2=NN=C(CC3=CC=C(OC)C=C3)C4=C2C=CC=C4)CC1)NC5=CC=C(Cl)C(C(F)(F)F)=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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CDK1-IN-3
Cat. No.:
HY-151407
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