CDK1-IN-4
Based on 1 publication(s) in Google Scholar
CDK1-IN-4 (10d) is a selective CDK1 inhibitor with IC50s of 44.52, 624.93 and 135.22 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN4 inhibits the growth of cancer cells by affecting cell cycle. CDK1-IN-4 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 3032997-16-0
- Formula: C26H24ClN5S
- Molecular Weight:474.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CDK1-IN-4
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Biological Activity
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CDK1 44.52 nM (IC50) |
CDK2 621.93 nM (IC50) |
CDK5 135.22 nM (IC50) |
CDK1-IN-4 (0-10 μM; 24 h) inhibits the growth of PDAC, melanoma, leukemia, colon and breast cancer cells[1]. CDK1-IN-4 (0-1 μM) inhibits CDK1, CDK2 and CDK5 with IC50s of 36.8, 305.17 and 369.37 nM, respectively[1]. CDK1-IN-4 (0-10 μM) inhibits AXL, PTK2B, FGFR, JAK1, IGF1R and BRAF kinases with IC50s of 2488, 8957, 7620, 8541, 4294 and 1156 nM, respectively[1]. CDK1-IN-4 (0.88 μM; 24 h) decreases CDK1 protein level in vitro and affects cell cycle[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PDAC, melanoma, leukemia, colon and breast cancer cell lines
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Concentration:0-10 μM
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Incubation Time:24 hours
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Result:Inhibited cell growth of PDAC, melanoma, leukemia, colon, and breast cancer cell over 69%, and inhibited MDA-PATC53 and PL45 cells with IC50s of 0.88 and 1.14 μM, respectively.
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Cell Line:MDA-PATC53 cell line
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Concentration:0.88 μM
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Incubation Time:24 hours
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Result:Downregulated CDK1 protein level compared to untreated cells.
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Cell Line:MDA-PATC53 cell line
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Concentration:0.88 μM
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Incubation Time:24 hours
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Result:Significantly arrested in G2/M phase of the cell cycle compared with the untreated cells.
Chemical Information
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CAS No. 3032997-16-0
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Molecular Weight 474.02
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Formula C26H24ClN5S
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SMILES
S=C(N1CCN(C2=NN=C(CC3=CC=CC=C3)C4=C2C=CC=C4)CC1)NC5=CC=CC(Cl)=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Exp Clin Cancer Res
Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis. [Abstract]2023 Sep 4;42(1):228. PMID: 37667382
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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