Aldh1a1 - aldehyde dehydrogenase family 1, subfamily A1 Gene

Also Known as E1; Ahd2; Ahd-2; Aldh1; ALHDII; Raldh1; ALDH-E1; Aldh1a2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11668

About Aldh1a1

Chromosome 19: 20,470,079-20,620,829 forward strand.GRCm39:CM001012.3

This gene has 6 transcripts (splice variants), 200 orthologues, 19 paralogues and is associated with 2 phenotypes. Biased expression in liver adult (RPKM 141.6), genital fat pad adult (RPKM 125.) and 12 other tissues.

Summary

Enables 3-chloroallyl aldehyde dehydrogenase activity and aminobutyraldehyde dehydrogenase activity. Involved in gamma-aminobutyric acid biosynthetic process and negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including optic cup morphogenesis involved in camera-type eye development; positive regulation of apoptotic process; and retinoid metabolic process. Located in axon and synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Apr 2022]

Aldh1a1 Products (5)

mRNA Protein Name
NM_001361505.1 NP_001348434.1 aldehyde dehydrogenase 1A1
NM_001361503.1 NP_001348432.1 aldehyde dehydrogenase 1A1
NM_013467.4 NP_038495.2 aldehyde dehydrogenase 1A1
NM_001361504.1 NP_001348433.1 aldehyde dehydrogenase 1A1
NM_001361506.1 NP_001348435.1 aldehyde dehydrogenase 1A1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables 3-chloroallyl aldehyde dehydrogenase activity IDA
IDA: Inferred from direct assay
12610736 MGI
enables aminobutyraldehyde dehydrogenase (NAD+) activity IMP
IMP: Inferred from mutant phenotype
26430123 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within 9-cis-retinoic acid biosynthetic process IDA
IDA: Inferred from direct assay
11876656 MGI
acts upstream of apoptotic process IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of or within embryonic eye morphogenesis IGI
IGI: Inferred from genetic interaction
16207763 MGI
involved in fructose catabolic process IDA
IDA: Inferred from direct assay
4343087 MGI
involved in gamma-aminobutyric acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
26430123 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
22561685 MGI
acts upstream of or within optic cup morphogenesis involved in camera-type eye development IGI
IGI: Inferred from genetic interaction
16611695 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
18971422 MGI
acts upstream of or within retinoic acid metabolic process IDA
IDA: Inferred from direct assay
10191271 MGI
acts upstream of or within retinoic acid metabolic process IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of or within retinoic acid metabolic process IMP
IMP: Inferred from mutant phenotype
12808103 MGI
acts upstream of or within retinol metabolic process IMP
IMP: Inferred from mutant phenotype
12851412 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in axon IDA
IDA: Inferred from direct assay
26430123 MGI
located in synapse IDA
IDA: Inferred from direct assay
26430123 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aldh1a1 Protein Structure

ALDH_F1AB_F2_RALDH1

ALDH_F1AB_F2_RALDH1: cd07141 (14 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
Protein Preferred Names Protein Names

aldehyde dehydrogenase 1A1

  • 3-deoxyglucosone dehydrogenase

  • RALDH 1

  • alcohol dehydrogenase family 1, subfamily A1

  • alcohol dehydrogenase family 1, subfamily A2

  • aldehyde dehydrogenase 1, liver cytosolic (class 1)

  • aldehyde dehydrogenase family 1 member A1

  • aldehyde dehydrogenase, cytosolic

  • retinal dehydrogenase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (36)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-138097 α-NETA ≥98.0% Unkown
HY-18768 NCT-501 99.59% Unkown
HY-125085 ALDH3A1-IN-3 Inhibitor 99.43% Unkown
HY-122912 ALDH1A inhibitor 673A 99.15% Unkown
HY-148466 IGUANA-1 Inhibitor 98.93% Unkown
HY-110294 CM037 Inhibitor 99.55% Unkown
HY-135841 CM010 Inhibitor 99.70% Unkown
HY-112278 NCT-506 Inhibitor 99.93% Unkown
HY-146683 KS106 99.87% Unkown
HY-146682 KS100 99.61% Unkown
HY-126003 ALDH1A1-IN-2 Inhibitor 99.31% Unkown
HY-112277 NCT-505 Inhibitor 99.37% Unkown
HY-123621 GNE-375 Inhibitor 99.93% Unkown
HY-155816 PROTAC NSD3 degrader-1 99.40% Unkown
HY-148243 IGUANA-1 free base Inhibitor 99.69% Unkown
HY-157567 FSI-TN42 Inhibitor 98.07% Unkown
HY-128299 ALDH3A1-IN-4 Inhibitor 99.91% Unkown
HY-134917 Aldi-2 Inhibitor / Unkown
HY-146240 ALDH1A1-IN-3 Inhibitor / Unkown
HY-157872 ALDH1A1-IN-4 Inhibitor / Unkown
HY-158026 ALDH1A1-IN-5 Inhibitor / Unkown
HY-159111 KS124 / Unkown
HY-187170 BM-51 Inhibitor / Unkown
HY-18768A NCT-501 hydrochloride Inhibitor / Unkown
HY-D3185 AlDeSense AM / Unkown
HY-D3442 ALDH2 probe 5 Ligand / Unkown
HY-RS00560 ALDH1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00561 Aldh1a1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00562 ALDH1A1 Rat Pre-designed siRNA Set A / Unkown
HY-RS00565 ALDH1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00566 ALDH1L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180872 ALDH1A1 modulator-1 / Unkown
HY-RS17566 Aldh1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21224 Aldh1l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24026 Aldh1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27740 Aldh1l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh1a1 NCBI NCBI:216