Baz2a - bromodomain adjacent to zinc finger domain, 2A Gene

Also Known as Tip5; Walp3; mKIAA0314; C030005G16Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 116848

Summary

Enables DNA binding activity; RNA binding activity; and lysine-acetylated histone binding activity. Involved in DNA methylation; histone deacetylation; and negative regulation of macromolecule metabolic process. Acts upstream of or within chromatin organization and histone modification. Located in nucleolus and rDNA heterochromatin. Part of chromatin silencing complex. Is expressed in several structures, including central nervous system; early conceptus; eye; genitourinary system; and paraxial mesenchyme. Orthologous to human BAZ2A (bromodomain adjacent to zinc finger domain 2A). [provided by Alliance of Genome Resources, Apr 2022]

Baz2a Products (1)

mRNA	Protein	Name
NM_054078.2	NP_473419.2	bromodomain adjacent to zinc finger domain protein 2A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11532953	MGI
enables RNA binding	IDA IDA: Inferred from direct assay	16678107	MGI
enables chromatin-protein adaptor activity	IDA IDA: Inferred from direct assay	12198165	MGI
enables lysine-acetylated histone binding	IDA IDA: Inferred from direct assay	16085498	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11532953	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in DNA methylation-dependent heterochromatin formation	IDA IDA: Inferred from direct assay	12198165	MGI
acts upstream of or within chromatin remodeling	IGI IGI: Inferred from genetic interaction	11532953	MGI
acts upstream of or within heterochromatin formation	IDA IDA: Inferred from direct assay	16678107	MGI
involved in heterochromatin formation	IDA IDA: Inferred from direct assay	16678107	MGI
acts upstream of or within heterochromatin formation	IMP IMP: Inferred from mutant phenotype	20168299	MGI
involved in negative regulation of transcription by RNA polymerase I	IDA IDA: Inferred from direct assay	12368916	MGI
involved in negative regulation of transcription by RNA polymerase I	IMP IMP: Inferred from mutant phenotype	12368916	MGI
acts upstream of or within rDNA heterochromatin formation	IDA IDA: Inferred from direct assay	16678107	MGI
involved in rDNA heterochromatin formation	IDA IDA: Inferred from direct assay	12198165	MGI
acts upstream of or within rDNA heterochromatin formation	IMP IMP: Inferred from mutant phenotype	20168299	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of NoRC complex	IPI IPI: Inferred from physical interaction	11532953	MGI
part of chromatin silencing complex	IDA IDA: Inferred from direct assay	16085498	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	11532953	MGI
located in rDNA heterochromatin	IDA IDA: Inferred from direct assay	12198165	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
bromodomain adjacent to zinc finger domain protein 2A	TTF-I-interacting protein 5 transcription termination factor I-interacting protein 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15658	GSK2801		99.86%	Unkown
HY-19336	BAZ2-ICR	Inhibitor	99.80%	Unkown
HY-77826	4-Chloro-N-methylpicolinamide	Inhibitor	99.89%	Unkown
HY-107477	GSK8573		99.53%	Unkown
HY-168448	dBAZ2	Degrader	/	Unkown
HY-168449	BAZ2A/B ligand 1		/	Unkown
HY-168453	dBAZ2B	Degrader	/	Unkown
HY-RS01379	BAZ2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18165	Baz2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24639	Baz2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Baz2a	NCBI	NCBI:11176