Apaf1 - apoptotic peptidase activating factor 1 Gene

Also Known as fog; Apaf-1; Apaf1l; mKIAA0413; 6230400I06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11783

Summary

Enables cysteine-type endopeptidase activator activity involved in apoptotic process and identical protein binding activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nervous system development; and regulation of apoptotic DNA fragmentation. Located in cytosol and nucleus. Is expressed in several structures, including inner cell mass; inner ear; limb interdigital region; liver; and vibrissa. Used to study Noonan syndrome. Orthologous to human APAF1 (apoptotic peptidase activating factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Apaf1 Products (3)

mRNA Protein Name
NM_001042558.1 NP_001036023.1 apoptotic protease-activating factor 1 isoform 1
NM_001282947.1 NP_001269876.1 apoptotic protease-activating factor 1 isoform 2
NM_009684.2 NP_033814.2 apoptotic protease-activating factor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
IDA: Inferred from direct assay
10830166 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
10830166 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IGI
IGI: Inferred from genetic interaction
15703386 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
15703386 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
9753321 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
9216040 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
16407291 MGI
acts upstream of or within multicellular organism development IMP
IMP: Inferred from mutant phenotype
9753320 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
9216040 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: Inferred from genetic interaction
15703386 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16183742 MGI
acts upstream of or within regulation of apoptotic DNA fragmentation IGI
IGI: Inferred from genetic interaction
15703386 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
15271982 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15271982 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

apoptotic protease-activating factor 1

  • forebrain overgrowth

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-126741 Azadirachtin 99.06% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Y0598 trans-Chalcone 99.25% Unkown
HY-18633 MDK83190 Activator 98.61% Unkown
HY-125018 QM31 Inhibitor 95.00% Unkown
HY-103349 PETCM 99.68% Unkown
HY-119979 Cardanol monoene Inducer 99.51% Unkown
HY-116692 Apoptosis inducer 34 99.9% Unkown
HY-136893 SP-6-27 / Unkown
HY-RS00801 APAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-171447 LPT99 Inhibitor / Unkown
HY-RS17757 Apaf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24224 Apaf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apaf1 NCBI NCBI:317