ANTXR2 - ANTXR cell adhesion molecule 2 Gene

Also Known as HFS; ISH; JHF; CMG2; CMG-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 118429

About ANTXR2

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:79,901,146-80,073,472 (from NCBI)

This gene has 13 transcripts (splice variants), 268 orthologues, 2 paralogues and is associated with 4 phenotypes. Broad expression in prostate (RPKM 24.4), endometrium (RPKM 22.7) and 21 other tissues.

Summary

This gene encodes a receptor for anthrax toxin. The protein binds to Collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

ANTXR2 Products (4)

mRNA Protein Name
NM_001145794.2 NP_001139266.1 anthrax toxin receptor 2 isoform 2 precursor
NM_001286780.2 NP_001273709.1 anthrax toxin receptor 2 isoform 3
NM_001286781.2 NP_001273710.1 anthrax toxin receptor 2 isoform 3
NM_058172.6 NP_477520.2 anthrax toxin receptor 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15044490 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANTXR2 Protein Structure

VWA

VWA: von Willebrand factor type A domain (44 - 199)

Anth_Ig

Anth_Ig: Anthrax receptor extracellular domain (215 - 318)

Ant_C

Ant_C: Anthrax receptor C-terminus region (394 - 484)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 489 a.a.
Protein Preferred Names Protein Names

anthrax toxin receptor 2

  • capillary morphogenesis gene 2 protein

ANTXR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
ANTXR2 P58335 pagA Bacillus anthracis P13423
ITC
15044490
Cross
ANTXR2 P58335 pagA Bacillus anthracis P13423
FRET
15044490
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANTXR2 Proteins

Cat. No. Product Name Accession Purity
HY-P76151 CMG-2/ANTXR2 Protein, Human (HEK293, Fc) P58335-4 (Q34-N317) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P700656 CMG-2/ANTXR2 Protein, Human (HEK293, His) P58335-4/NP_477520.2 (Q34-G318) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hyaline Fibromatosis Syndrome

  • Juvenile Hyaline Fibromatosis

  • Inherited Systemic Hyalinosis

  • Puretic Syndrome

  • Infantile Systemic Hyalinosis

  • HFS

  • Hyalinosis, Systemic

  • Systemic Hyalinosis

  • Molluscum Fibrosum

  • Murray Syndrome

  • Murray-Puretic-Drescher Syndrome

  • Ish

  • Jhf

  • Fibromatosis, Juvenile Hyaline

  • Hyalinosis, Systemic Infantile

  • Fibromatosis, Hyaline Syndrome

  • Neurofibromatosis 1
Fibromatosis
Gingival Hypertrophy

  • Hypertrophy Of Gingivae
Anthrax Disease

  • Anthrax

  • Ragpicker'S Disease

  • Black Baine

  • Malignant Edema

  • Malignant Pustule

  • Siberian Plague

  • Wool Sorter'S Disease

  • Gas Gangrene

  • Cutaneous Anthrax

  • Anthrax Infection

  • Splenic Fever
Inhalation Anthrax

  • Pulmonary Anthrax

  • Respiratory Anthrax

  • Inhalational Anthrax

  • Wool-Sorters' Disease

  • Woolsorters' Disease

  • Inhalation Anthrax Disease

  • Respiratory Anthrax Disease
Cutaneous Anthrax

  • Anthrax, Skin Type

  • Skin Anthrax
Gastrointestinal Anthrax
Oropharyngeal Anthrax
Diarrhea

  • Diarrhoea

  • Diarrhea Of Presumed Infectious Origin
Gapo Syndrome

  • GAPOS

  • Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy

  • Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome

  • Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy
Lipoid Proteinosis Of Urbach And Wiethe

  • Lipoid Proteinosis

  • Urbach-Wiethe Disease

  • Hyalinosis Cutis Et Mucosae

  • Lipid Proteinosis

  • Lipoproteinosis

  • Urbach Wiethe Disease

  • Lipoglycoproteinosis

  • Lipoidosis Cutis Et Mucosae

  • Lipoidproteinosis

  • Urbach-Wiethe Lipoid Proteinosis

  • Urbach-Wiethe Syndrome

  • LIP

  • Proteinosis Lipoid
Winchester Syndrome

  • WNCHRS

  • Winchester Disease

  • Winchester-Grossman Syndrome
Protein-Losing Enteropathy

  • Protein-Losing Enteropathies

  • Enteropathy, Exudative

  • Exudative Enteropathy

  • Ple - [Protein-Losing Enteropathy]
Gingival Disease

  • Gingival Diseases

  • Gum Disease

  • Gingival Disorder

  • Gingivitis And Periodontal Diseases
Stiff Skin Syndrome

  • SSKS

  • Stiff Skin
Oculoglandular Tularemia
Gingival Fibromatosis

  • Hereditary Gingival Fibromatosis

  • Hereditary Gingival Hyperplasia

  • Autosomal Dominant Gingival Fibromatosis

  • Autosomal Dominant Gingival Hyperplasia

  • Fibromatosis, Gingival, Hereditary

  • Fibromatosis, Gingival
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00756 ANTXR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18695 Antxr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25182 Antxr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ANTXR2 VGNC VGNC:25962
Rattus norvegicus ANTXR2 RGD RGD:1561294
Felis catus ANTXR2 VGNC VGNC:59838
Canis familiaris ANTXR2 VGNC VGNC:37936
Macaca mulatta ANTXR2 VGNC VGNC:69881
Mus musculus ANTXR2 MGD MGI:1919164
Others ANTXR2 NCBI