Bach2 - BTB and CNC homology, basic leucine zipper transcription factor 2 Gene

Also Known as E030004N02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12014

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in import into nucleus and negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including central nervous system; limb bud; reproductive system; retina; and urinary system. Human ortholog(s) of this gene implicated in immunodeficiency 60. Orthologous to human BACH2 (BTB domain and CNC homolog 2). [provided by Alliance of Genome Resources, Apr 2022]

Bach2 Products (1)

mRNA Protein Name
NM_001109661.1 NP_001103131.1 transcription regulator protein BACH2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
8887638 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
8887638 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8887638 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8887638 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8887638 MGI
Biological Process GO Annotation Evidence References Source
involved in import into nucleus IMP
IMP: Inferred from mutant phenotype
26021350 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8887638 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8887638 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
8887638 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription regulator protein BACH2

  • BTB and CNC homolog 2

  • BTB and CNC homology 2

  • Transcription regulator protein BACH2 (BTB and CNC homolog 2)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19986 Bach2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01340 BACH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26490 Bach2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bach2 NCBI NCBI:60468